Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3663610..3664228 Replicon chromosome
Accession NZ_CP072687
Organism Escherichia coli strain YP3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag J8I95_RS17710 Protein ID WP_001291435.1
Coordinates 3664010..3664228 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag J8I95_RS17705 Protein ID WP_000344800.1
Coordinates 3663610..3663984 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I95_RS17695 (3658700) 3658700..3659893 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J8I95_RS17700 (3659916) 3659916..3663065 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
J8I95_RS17705 (3663610) 3663610..3663984 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
J8I95_RS17710 (3664010) 3664010..3664228 + 219 WP_001291435.1 HHA domain-containing protein Toxin
J8I95_RS17715 (3664401) 3664401..3664952 + 552 WP_000102539.1 maltose O-acetyltransferase -
J8I95_RS17720 (3665068) 3665068..3665538 + 471 WP_000136192.1 YlaC family protein -
J8I95_RS17725 (3665702) 3665702..3667252 + 1551 WP_001468081.1 cyclic-guanylate-specific phosphodiesterase PdeB -
J8I95_RS17730 (3667294) 3667294..3667647 - 354 WP_000878142.1 DUF1428 family protein -
J8I95_RS17740 (3668026) 3668026..3668337 + 312 WP_000409908.1 MGMT family protein -
J8I95_RS17745 (3668368) 3668368..3668940 - 573 WP_000779844.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T198277 WP_001291435.1 NZ_CP072687:3664010-3664228 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T198277 NZ_CP096844:1690413-1690730 [Mycobacterium tuberculosis variant bovis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT198277 WP_000344800.1 NZ_CP072687:3663610-3663984 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT198277 NZ_CP096844:1690114-1690416 [Mycobacterium tuberculosis variant bovis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References