Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2585123..2586711 | Replicon | chromosome |
| Accession | NZ_CP072686 | ||
| Organism | Escherichia coli strain FP4 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | B7MMY1 |
| Locus tag | J8I94_RS12540 | Protein ID | WP_001125475.1 |
| Coordinates | 2585389..2586711 (+) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | J8I94_RS12535 | Protein ID | WP_001332145.1 |
| Coordinates | 2585123..2585389 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8I94_RS12520 (2581491) | 2581491..2582942 | + | 1452 | WP_000854636.1 | tagaturonate reductase | - |
| J8I94_RS12525 (2583139) | 2583139..2584053 | + | 915 | WP_001306069.1 | bestrophin family protein | - |
| J8I94_RS12530 (2584057) | 2584057..2584815 | - | 759 | WP_001286588.1 | trans-aconitate 2-methyltransferase | - |
| J8I94_RS12535 (2585123) | 2585123..2585389 | + | 267 | WP_001332145.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| J8I94_RS12540 (2585389) | 2585389..2586711 | + | 1323 | WP_001125475.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
| J8I94_RS12545 (2586890) | 2586890..2587156 | - | 267 | WP_001527024.1 | hypothetical protein | - |
| J8I94_RS12550 (2587167) | 2587167..2587961 | - | 795 | WP_001527023.1 | hypothetical protein | - |
| J8I94_RS12555 (2588029) | 2588029..2588451 | - | 423 | WP_001527022.1 | hypothetical protein | - |
| J8I94_RS12560 (2588551) | 2588551..2588997 | - | 447 | WP_000527682.1 | helix-turn-helix transcriptional regulator | - |
| J8I94_RS12565 (2589169) | 2589169..2590221 | + | 1053 | WP_000568107.1 | phage/plasmid replication protein, II/X family | - |
| J8I94_RS12570 (2590233) | 2590233..2590550 | + | 318 | WP_000073835.1 | DNA-binding protein | - |
| J8I94_RS12575 (2590553) | 2590553..2590804 | + | 252 | WP_001536107.1 | hypothetical protein | - |
| J8I94_RS12580 (2590839) | 2590839..2591072 | + | 234 | WP_000473544.1 | hypothetical protein | - |
| J8I94_RS12585 (2591158) | 2591158..2591472 | + | 315 | Protein_2469 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49426.24 Da Isoelectric Point: 8.9380
>T198252 WP_001125475.1 NZ_CP072686:2585389-2586711 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRRNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVMCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVKRFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
>T198252 NZ_CP096844:71513-71914 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.44 Da Isoelectric Point: 6.2267
>AT198252 WP_001332145.1 NZ_CP072686:2585123-2585389 [Escherichia coli]
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW
MMSFQKIYSPMQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPNNTSLTTFFKILQSLELSMTLCDAKNASPEA
TEQQDLEW
Download Length: 267 bp
>AT198252 NZ_CP096844:71281-71520 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|