Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1428138..1428683 | Replicon | chromosome |
| Accession | NZ_CP072680 | ||
| Organism | Vibrio sp. SCSIO 43186 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | J8Z27_RS06885 | Protein ID | WP_252036463.1 |
| Coordinates | 1428138..1428434 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A7X8YLC8 |
| Locus tag | J8Z27_RS06890 | Protein ID | WP_005526987.1 |
| Coordinates | 1428441..1428683 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8Z27_RS06840 (J8Z27_06775) | 1423906..1424160 | + | 255 | WP_252036457.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| J8Z27_RS06845 (J8Z27_06780) | 1424153..1424422 | + | 270 | WP_252036458.1 | Txe/YoeB family addiction module toxin | - |
| J8Z27_RS06850 (J8Z27_06785) | 1424601..1424915 | + | 315 | WP_252036459.1 | hypothetical protein | - |
| J8Z27_RS06855 (J8Z27_06795) | 1425472..1425624 | + | 153 | WP_252036460.1 | hypothetical protein | - |
| J8Z27_RS06860 (J8Z27_06800) | 1425625..1426389 | + | 765 | WP_252036619.1 | PhzF family phenazine biosynthesis protein | - |
| J8Z27_RS06865 (J8Z27_06805) | 1426407..1426496 | + | 90 | WP_239871702.1 | DUF3265 domain-containing protein | - |
| J8Z27_RS06870 (J8Z27_06810) | 1426524..1426793 | + | 270 | WP_252036461.1 | hypothetical protein | - |
| J8Z27_RS06875 (J8Z27_06815) | 1426938..1427357 | + | 420 | WP_252036358.1 | hypothetical protein | - |
| J8Z27_RS06880 (J8Z27_06820) | 1427481..1427966 | + | 486 | WP_252036462.1 | GNAT family N-acetyltransferase | - |
| J8Z27_RS06885 (J8Z27_06825) | 1428138..1428434 | - | 297 | WP_252036463.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J8Z27_RS06890 (J8Z27_06830) | 1428441..1428683 | - | 243 | WP_005526987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J8Z27_RS06900 | 1430502..1430645 | + | 144 | WP_252036465.1 | hypothetical protein | - |
| J8Z27_RS06905 | 1430664..1430894 | + | 231 | WP_252036466.1 | hypothetical protein | - |
| J8Z27_RS06910 (J8Z27_06845) | 1431116..1432456 | - | 1341 | WP_252036467.1 | BspA family leucine-rich repeat surface protein | - |
| J8Z27_RS06915 (J8Z27_06850) | 1432495..1432932 | - | 438 | WP_252036468.1 | BspA family leucine-rich repeat surface protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1303177..1430025 | 126848 | |
| - | inside | Integron | - | - | 1302170..1428889 | 126719 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11249.88 Da Isoelectric Point: 9.8450
>T198233 WP_252036463.1 NZ_CP072680:c1428434-1428138 [Vibrio sp. SCSIO 43186]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSQLPQNHL
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSQLPQNHL
Download Length: 297 bp
>T198233 NZ_CP096843:c2379094-2378777 [Mycobacterium tuberculosis variant bovis]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8974.16 Da Isoelectric Point: 4.7914
>AT198233 WP_005526987.1 NZ_CP072680:c1428683-1428441 [Vibrio sp. SCSIO 43186]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL
Download Length: 243 bp
>AT198233 NZ_CP096843:c2379306-2379091 [Mycobacterium tuberculosis variant bovis]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|