Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relB-yefM/YoeB-RelB |
| Location | 1423906..1424422 | Replicon | chromosome |
| Accession | NZ_CP072680 | ||
| Organism | Vibrio sp. SCSIO 43186 | ||
Toxin (Protein)
| Gene name | relB | Uniprot ID | - |
| Locus tag | J8Z27_RS06845 | Protein ID | WP_252036458.1 |
| Coordinates | 1424153..1424422 (+) | Length | 90 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | J8Z27_RS06840 | Protein ID | WP_252036457.1 |
| Coordinates | 1423906..1424160 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8Z27_RS06805 (J8Z27_06740) | 1418966..1419379 | + | 414 | WP_252036452.1 | hypothetical protein | - |
| J8Z27_RS06810 (J8Z27_06745) | 1419383..1420705 | - | 1323 | WP_252040103.1 | IS4 family transposase | - |
| J8Z27_RS06815 (J8Z27_06750) | 1421307..1421483 | + | 177 | WP_252036454.1 | hypothetical protein | - |
| J8Z27_RS06820 (J8Z27_06755) | 1421594..1422304 | + | 711 | WP_252036455.1 | hypothetical protein | - |
| J8Z27_RS06825 (J8Z27_06760) | 1422495..1422908 | + | 414 | WP_038162647.1 | RDD family protein | - |
| J8Z27_RS06830 (J8Z27_06765) | 1422927..1423019 | + | 93 | WP_072612521.1 | DUF3265 domain-containing protein | - |
| J8Z27_RS06835 (J8Z27_06770) | 1423061..1423687 | + | 627 | WP_252036456.1 | LysE family translocator | - |
| J8Z27_RS06840 (J8Z27_06775) | 1423906..1424160 | + | 255 | WP_252036457.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| J8Z27_RS06845 (J8Z27_06780) | 1424153..1424422 | + | 270 | WP_252036458.1 | Txe/YoeB family addiction module toxin | Toxin |
| J8Z27_RS06850 (J8Z27_06785) | 1424601..1424915 | + | 315 | WP_252036459.1 | hypothetical protein | - |
| J8Z27_RS06855 (J8Z27_06795) | 1425472..1425624 | + | 153 | WP_252036460.1 | hypothetical protein | - |
| J8Z27_RS06860 (J8Z27_06800) | 1425625..1426389 | + | 765 | WP_252036619.1 | PhzF family phenazine biosynthesis protein | - |
| J8Z27_RS06865 (J8Z27_06805) | 1426407..1426496 | + | 90 | WP_239871702.1 | DUF3265 domain-containing protein | - |
| J8Z27_RS06870 (J8Z27_06810) | 1426524..1426793 | + | 270 | WP_252036461.1 | hypothetical protein | - |
| J8Z27_RS06875 (J8Z27_06815) | 1426938..1427357 | + | 420 | WP_252036358.1 | hypothetical protein | - |
| J8Z27_RS06880 (J8Z27_06820) | 1427481..1427966 | + | 486 | WP_252036462.1 | GNAT family N-acetyltransferase | - |
| J8Z27_RS06885 (J8Z27_06825) | 1428138..1428434 | - | 297 | WP_252036463.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J8Z27_RS06890 (J8Z27_06830) | 1428441..1428683 | - | 243 | WP_005526987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1303177..1430025 | 126848 | |
| - | flank | IS/Tn | - | - | 1419383..1420705 | 1322 | |
| - | inside | Integron | - | - | 1302170..1428889 | 126719 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10600.93 Da Isoelectric Point: 7.9816
>T198232 WP_252036458.1 NZ_CP072680:1424153-1424422 [Vibrio sp. SCSIO 43186]
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
MSSSQRLLSWTDDAWDDYLYWQTQDKKTLKRINKLINDVKRSPFEGIGKPEPLKENLSGFWSRRVDDTNRLVYAVDDQAI
TIISCRYHY
Download Length: 270 bp
>T198232 NZ_CP096843:c2342431-2341997 [Mycobacterium tuberculosis variant bovis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9483.63 Da Isoelectric Point: 5.0623
>AT198232 WP_252036457.1 NZ_CP072680:1423906-1424160 [Vibrio sp. SCSIO 43186]
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
MRIVSFTEARNGLKAVLDGVVNDADTTVITRRDSEDAVVMSLDYYNSLMETVHLLRSPQNAEHLNRSIAQYRAGKTTTRE
LIDE
Download Length: 255 bp
>AT198232 NZ_CP096843:c2342692-2342438 [Mycobacterium tuberculosis variant bovis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|