Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1414390..1414935 | Replicon | chromosome |
| Accession | NZ_CP072680 | ||
| Organism | Vibrio sp. SCSIO 43186 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | J8Z27_RS06765 | Protein ID | WP_252036446.1 |
| Coordinates | 1414390..1414686 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A7X8YLC8 |
| Locus tag | J8Z27_RS06770 | Protein ID | WP_005526987.1 |
| Coordinates | 1414693..1414935 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8Z27_RS06720 (J8Z27_06660) | 1409441..1409860 | + | 420 | WP_252036440.1 | lysozyme inhibitor LprI family protein | - |
| J8Z27_RS06725 (J8Z27_06665) | 1409981..1410343 | + | 363 | WP_252036441.1 | hypothetical protein | - |
| J8Z27_RS06730 (J8Z27_06670) | 1410588..1410956 | + | 369 | WP_252036442.1 | hypothetical protein | - |
| J8Z27_RS06735 (J8Z27_06675) | 1410959..1411342 | + | 384 | WP_252036443.1 | hypothetical protein | - |
| J8Z27_RS06740 (J8Z27_06680) | 1411805..1411954 | + | 150 | WP_252036444.1 | hypothetical protein | - |
| J8Z27_RS06745 (J8Z27_06685) | 1412736..1412888 | + | 153 | WP_252036460.1 | hypothetical protein | - |
| J8Z27_RS06750 (J8Z27_06690) | 1412889..1413653 | + | 765 | WP_252036619.1 | PhzF family phenazine biosynthesis protein | - |
| J8Z27_RS06755 (J8Z27_06695) | 1413671..1413760 | + | 90 | WP_239871702.1 | DUF3265 domain-containing protein | - |
| J8Z27_RS06760 (J8Z27_06700) | 1413807..1414214 | + | 408 | WP_252036445.1 | GFA family protein | - |
| J8Z27_RS06765 (J8Z27_06705) | 1414390..1414686 | - | 297 | WP_252036446.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J8Z27_RS06770 (J8Z27_06710) | 1414693..1414935 | - | 243 | WP_005526987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| J8Z27_RS06775 (J8Z27_06715) | 1415740..1416174 | + | 435 | WP_252036447.1 | hypothetical protein | - |
| J8Z27_RS06780 | 1416201..1416293 | + | 93 | WP_252036448.1 | DUF3265 domain-containing protein | - |
| J8Z27_RS06785 (J8Z27_06720) | 1416333..1416737 | + | 405 | WP_252036449.1 | GFA family protein | - |
| J8Z27_RS06790 (J8Z27_06725) | 1416866..1417336 | + | 471 | WP_252036393.1 | hypothetical protein | - |
| J8Z27_RS06795 (J8Z27_06730) | 1417967..1418263 | + | 297 | WP_252036450.1 | DUF6506 family protein | - |
| J8Z27_RS06800 (J8Z27_06735) | 1418421..1418831 | + | 411 | WP_252036451.1 | hypothetical protein | - |
| J8Z27_RS06805 (J8Z27_06740) | 1418966..1419379 | + | 414 | WP_252036452.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1303177..1430025 | 126848 | |
| - | flank | IS/Tn | - | - | 1419383..1420705 | 1322 | |
| - | inside | Integron | - | - | 1302170..1428889 | 126719 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11253.88 Da Isoelectric Point: 9.6430
>T198231 WP_252036446.1 NZ_CP072680:c1414686-1414390 [Vibrio sp. SCSIO 43186]
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPAGKHTAYFTKEDC
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQTHLRKIKSYTVNNFSETQWRSYKDTLLTGFQMLADNPAVGRSCDDIYPSGFYFPAGKHTAYFTKEDC
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T198231 NZ_CP096843:2301046-2301456 [Mycobacterium tuberculosis variant bovis]
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
TTGGCTGAGCCACGGCGAGGAGACCTTTGGCTGGTCAGCCTCGGCGCCGCTCGCGCGGGTGAGCCCGGCAAGCATCGGCC
CGCGGTGGTCGTTTCCGTGGACGAGCTACTCACCGGAATCGACGACGAACTCGTTGTCGTCGTGCCGGTGTCAAGCTCGC
GCTCCCGCACCCCACTCCGGCCACCTGTCGCGCCCTCAGAAGGTGTAGCTGCCGATAGCGTCGCGGTGTGCCGCGGCGTC
CGCGCGGTCGCTCGTGCCCGACTCGTGGAGCGACTCGGCGCCCTCAAACCCGCCACGATGCGCGCAATCGAAAACGCCCT
GACCCTGATCCTCGGCCTCCCGACGGGACCTGAGCGCGGCGAGGCGGCGACCCATTCTCCCGTACGGTGGACGGGTGGCC
GGGACCCGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8974.16 Da Isoelectric Point: 4.7914
>AT198231 WP_005526987.1 NZ_CP072680:c1414935-1414693 [Vibrio sp. SCSIO 43186]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKTDYLKHCFESAKQDLAQGNVVDGEDFLNAL
Download Length: 243 bp
>AT198231 NZ_CP096843:2300820-2301053 [Mycobacterium tuberculosis variant bovis]
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
ATGTCTACATCCACGACGATTAGGGTTTCAACCCAGACTCGGGATCGTCTGGCCGCCCAAGCCCGCGAACGGGGAATCTC
GATGTCGGCTCTGCTCACCGAACTGGCCGCCCAGGCCGAGCGCCAGGCAATCTTCCGCGCCGAACGCGAGGCCTCGCACG
CCGAGACGACCACCCAGGCAGTCCGCGACGAGGACCGCGAGTGGGAGGGCACGGTAGGCGACGGCCTTGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|