Detailed information of TA system TA198225

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1713336..1713851
• Replicon: chromosome
• Accession: NZ_CP072656
• Organism: Micrococcus luteus strain MT1691313

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J7660_RS07730
• Protein ID: WP_134416751.1
• Coordinates: 1713336..1713590 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: J7660_RS07735
• Protein ID: WP_134416753.1
• Coordinates: 1713591..1713851 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7660_RS07700 (J7660_07700)	1708842..1710248	+	1407	WP_163721243.1	Dyp-type peroxidase	-
J7660_RS07705 (J7660_07705)	1710245..1710634	+	390	WP_163721241.1	hypothetical protein	-
J7660_RS07710 (J7660_07710)	1710666..1711403	+	738	WP_205521335.1	histidine phosphatase family protein	-
J7660_RS07715 (J7660_07715)	1711400..1711942	+	543	WP_134416745.1	DUF3090 domain-containing protein	-
J7660_RS07720 (J7660_07720)	1711942..1712724	+	783	WP_134416747.1	SCO1664 family protein	-
J7660_RS07725 (J7660_07725)	1712768..1713334	-	567	WP_134416749.1	mismatch-specific DNA-glycosylase	-
J7660_RS07730 (J7660_07730)	1713336..1713590	-	255	WP_134416751.1	Txe/YoeB family addiction module toxin	Toxin
J7660_RS07735 (J7660_07735)	1713591..1713851	-	261	WP_134416753.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
J7660_RS07740 (J7660_07740)	1713979..1715322	+	1344	WP_044658726.1	IS256-like element ISMlu11 family transposase	-
J7660_RS11265	1715497..1715640	+	144	WP_225348956.1	hypothetical protein	-
J7660_RS07745 (J7660_07745)	1715637..1716578	+	942	WP_242821290.1	hypothetical protein	-
J7660_RS07750 (J7660_07750)	1716608..1717762	+	1155	WP_134416956.1	glycerate kinase	-
J7660_RS07755 (J7660_07755)	1717758..1718174	+	417	Protein_1504	phosphatidylinositol kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1713973..1715322	1349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10024.39 Da
• Isoelectric Point: 7.3149

>T198225 WP_134416751.1 NZ_CP072656:c1713590-1713336 [Micrococcus luteus]
VRLVWDRSAWEDYTHWQTTDRKVLKRINTLIDAALRDPFDGIGKPEQLKYGAPGAWSRRITEEHRLVYLVDGEDLIILQV
RYHY

Nucleotide

• Length: 255 bp

>T198225 NZ_CP096843:2189426-2189803 [Mycobacterium tuberculosis variant bovis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9639.82 Da
• Isoelectric Point: 4.8483

>AT198225 WP_134416753.1 NZ_CP072656:c1713851-1713591 [Micrococcus luteus]
MSISASEARKTLFPLIERVNADREVVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDAYERARAGSVEEHALD
RMDGDA

Nucleotide

• Length: 261 bp

>AT198225 NZ_CP096843:2189845-2190294 [Mycobacterium tuberculosis variant bovis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA