Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 753882..754539 Replicon chromosome
Accession NZ_CP072653
Organism Klebsiella pneumoniae strain KPN234

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag J8J76_RS03765 Protein ID WP_002916310.1
Coordinates 754129..754539 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J8J76_RS03760 Protein ID WP_002916312.1
Coordinates 753882..754148 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8J76_RS03735 (J8J76_03735) 749038..750471 - 1434 WP_069339816.1 6-phospho-beta-glucosidase -
J8J76_RS03740 (J8J76_03740) 750590..751318 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J8J76_RS03745 (J8J76_03745) 751368..751679 + 312 WP_069339815.1 N(4)-acetylcytidine aminohydrolase -
J8J76_RS03750 (J8J76_03750) 751843..752502 + 660 WP_002916317.1 hemolysin III family protein -
J8J76_RS03755 (J8J76_03755) 752653..753636 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J8J76_RS03760 (J8J76_03760) 753882..754148 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J8J76_RS03765 (J8J76_03765) 754129..754539 + 411 WP_002916310.1 protein YgfX Toxin
J8J76_RS03770 (J8J76_03770) 754546..755067 - 522 WP_004144730.1 flavodoxin FldB -
J8J76_RS03775 (J8J76_03775) 755168..756064 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J8J76_RS03780 (J8J76_03780) 756087..756800 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J8J76_RS03785 (J8J76_03785) 756806..758539 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T198205 WP_002916310.1 NZ_CP072653:754129-754539 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T198205 NZ_CP096843:717725-718120 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT198205 WP_002916312.1 NZ_CP072653:753882-754148 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT198205 NZ_CP096843:717471-717725 [Mycobacterium tuberculosis variant bovis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References