Detailed information of TA system TA198199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 2123428..2124051
• Replicon: chromosome
• Accession: NZ_CP072652
• Organism: Serratia symbiotica strain 24.1

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E9CPA8
• Locus tag: GPZ83_RS11005
• Protein ID: WP_006709525.1
• Coordinates: 2123848..2124051 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: GPZ83_RS11000
• Protein ID: WP_040266826.1
• Coordinates: 2123428..2123796 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GPZ83_RS10980 (GPZ83_0010975)	2118930..2119808	-	879	WP_040266823.1	metal ABC transporter substrate-binding protein	-
GPZ83_RS10985 (GPZ83_0010980)	2119836..2120693	-	858	WP_040266824.1	metal ABC transporter permease	-
GPZ83_RS10990 (GPZ83_0010985)	2120690..2121403	-	714	WP_040267096.1	ABC transporter ATP-binding protein	-
GPZ83_RS10995 (GPZ83_0010990)	2121812..2122912	+	1101	Protein_2010	ISAs1 family transposase	-
GPZ83_RS11000 (GPZ83_0010995)	2123428..2123796	+	369	WP_040266826.1	Hha toxicity modulator TomB	Antitoxin
GPZ83_RS11005 (GPZ83_0011000)	2123848..2124051	+	204	WP_006709525.1	HHA domain-containing protein	Toxin
GPZ83_RS11015 (GPZ83_0011010)	2125004..2125318	+	315	WP_160758454.1	MGMT family protein	-
GPZ83_RS11020 (GPZ83_0011015)	2125404..2126267	+	864	WP_160744601.1	acyl-CoA thioesterase II	-
GPZ83_RS11025 (GPZ83_0011020)	2126525..2127811	-	1287	WP_040266836.1	ammonium transporter AmtB	-
GPZ83_RS11030 (GPZ83_0011025)	2127846..2128184	-	339	WP_040266837.1	P-II family nitrogen regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8090.38 Da
• Isoelectric Point: 7.9816

>T198199 WP_006709525.1 NZ_CP072652:2123848-2124051 [Serratia symbiotica]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSNDELELFYSAADHRLAELTMNKLYDKIPTAVWKYVR

Nucleotide

• Length: 204 bp

>T198199 NZ_CP096843:c445743-445150 [Mycobacterium tuberculosis variant bovis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14310.10 Da
• Isoelectric Point: 4.3383

>AT198199 WP_040266826.1 NZ_CP072652:2123428-2123796 [Serratia symbiotica]
MDEYSSKRHDIAQLKFLCENLYDEGIATLDDSYHGWVNDPTSFVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDAYMLFSSYGINDSDLRRWQKTKAKLFRMFSGEGICTTMKT

Nucleotide

• Length: 369 bp

>AT198199 NZ_CP096843:c446161-445772 [Mycobacterium tuberculosis variant bovis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Structures

Toxin

• AlphaFold DB: A0A068R9C7