Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 677685..678430 Replicon chromosome
Accession NZ_CP072652
Organism Serratia symbiotica strain 24.1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag GPZ83_RS04140 Protein ID WP_040263016.1
Coordinates 677685..678176 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag GPZ83_RS04145 Protein ID WP_040263014.1
Coordinates 678164..678430 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GPZ83_RS04120 (GPZ83_0004115) 673482..674141 - 660 WP_146226729.1 lipoyl(octanoyl) transferase LipB -
GPZ83_RS04125 (GPZ83_0004120) 674283..674549 - 267 WP_040263021.1 DUF493 family protein YbeD -
GPZ83_RS04130 (GPZ83_0004125) 675074..675783 - 710 Protein_661 IS1 family transposase -
GPZ83_RS04135 (GPZ83_0004130) 676243..677454 - 1212 WP_040263018.1 D-alanyl-D-alanine carboxypeptidase DacA -
GPZ83_RS04140 (GPZ83_0004135) 677685..678176 - 492 WP_040263016.1 GNAT family N-acetyltransferase Toxin
GPZ83_RS04145 (GPZ83_0004140) 678164..678430 - 267 WP_040263014.1 DUF1778 domain-containing protein Antitoxin
GPZ83_RS04150 (GPZ83_0004145) 678773..679703 - 931 Protein_665 endolytic peptidoglycan transglycosylase RlpA -
GPZ83_RS04155 (GPZ83_0004150) 679714..680826 - 1113 WP_040263012.1 peptidoglycan glycosyltransferase MrdB -
GPZ83_RS04160 (GPZ83_0004155) 680838..682733 - 1896 WP_040263010.1 peptidoglycan DD-transpeptidase MrdA -
GPZ83_RS04165 (GPZ83_0004160) 682769..683239 - 471 WP_040263008.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17861.71 Da        Isoelectric Point: 9.9670

>T198197 WP_040263016.1 NZ_CP072652:c678176-677685 [Serratia symbiotica]
VGKVTAPTPLNTTHILSEFHSRETALDEWIKHQGLKNQSIGAARTFVVCREHSSQVVGFYSLATGSVTHVIAPRSLRRNM
PDPIPVIILARLAVDAGYHGKGLGADLLHDAVLRICRVAENIGVRAIMVHTLSDAAKQFYLHHGLMQSTTQEKTLFLRLP
GIV

Download         Length: 492 bp

>T198197 NZ_CP096843:364433-364735 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10113.57 Da        Isoelectric Point: 4.4857

>AT198197 WP_040263014.1 NZ_CP072652:c678430-678164 [Serratia symbiotica]
MKSDVQLNIRAKEAQRVLIDTAADILHKSRTDFILEIACQAAENVLLDRRMFNLNDEQYAEFIDMLDEPVTANPALDALL
ARKPQWEK

Download         Length: 267 bp

>AT198197 NZ_CP096843:364783-365004 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References