Detailed information of TA system TA198195

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/DUF433(antitoxin)
• Location: 636990..637552
• Replicon: chromosome
• Accession: NZ_CP072649
• Organism: Chloracidobacterium validum strain BV2-C

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J8C06_RS13785
• Protein ID: WP_211430005.1
• Coordinates: 637211..637552 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J8C06_RS13780
• Protein ID: WP_211430004.1
• Coordinates: 636990..637214 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8C06_RS13755 (J8C06_13755)	632564..632881	-	318	WP_211430000.1	tyrosine-type recombinase/integrase	-
J8C06_RS13760 (J8C06_13760)	633313..633591	+	279	WP_211430001.1	hypothetical protein	-
J8C06_RS13765 (J8C06_13765)	634641..635420	+	780	WP_246602186.1	arsenite methyltransferase	-
J8C06_RS13770 (J8C06_13770)	635486..635953	+	468	WP_211430003.1	hypothetical protein	-
J8C06_RS13775 (J8C06_13775)	636173..636574	+	402	WP_281423865.1	ATP-binding protein	-
J8C06_RS13780 (J8C06_13780)	636990..637214	+	225	WP_211430004.1	DUF433 domain-containing protein	Antitoxin
J8C06_RS13785 (J8C06_13785)	637211..637552	+	342	WP_211430005.1	DUF5615 family PIN-like protein	Toxin
J8C06_RS13790 (J8C06_13790)	637732..638127	+	396	WP_281423866.1	2,4'-dihydroxyacetophenone dioxygenase family protein	-
J8C06_RS13795 (J8C06_13795)	638709..638989	+	281	Protein_521	type II toxin-antitoxin system RelE/ParE family toxin	-
J8C06_RS13800 (J8C06_13800)	639006..639289	+	284	Protein_522	HigA family addiction module antitoxin	-
J8C06_RS13805 (J8C06_13805)	640033..640503	+	471	WP_281423867.1	ATP-binding protein	-
J8C06_RS13810 (J8C06_13810)	640848..641642	+	795	WP_211430007.1	hypothetical protein	-
J8C06_RS13815 (J8C06_13815)	641661..642008	+	348	WP_211430008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	627845..671028	43183
	-	inside	Integron	-	-	634383..651732	17349

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Domain of unknown function DUF5615 (4-79)

Antitoxin

• Protein of unknown function DUF433 (8-63)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12429.28 Da
• Isoelectric Point: 4.2796

>T198195 WP_211430005.1 NZ_CP072649:637211-637552 [Chloracidobacterium validum]
MTTIWIDAHLSPAIATWIADTFGVTALALRDLGLRNAEDLEIFEAAKSQGVIFMTKDSDFVDLVERLDSPPQIIWLTCGN
TSNAKLREILSSVLPKTLELLRSGEKLVEISGD

Nucleotide

• Length: 342 bp

>T198195 NZ_CP096843:71513-71914 [Mycobacterium tuberculosis variant bovis]
GTGGATGAATGTGTAGTCGACGCGGCGGCCGTGGTTGACGCTCTCGCCGGCAAGGGCGCCAGCGCGATCGTTCTGCGCGG
TTTGCTCAAGGAGTCGATTTCTAACGCGCCGCATTTGCTGGACGCAGAGGTCGGACATGCACTCCGCCGCGCCGTGCTCA
GCGACGAAATCTCCGAAGAGCAGGCTCGCGCCGCGTTGGATGCCTTGCCTTATCTCATCGACAATCGTTACCCGCACAGC
CCACGACTGATCGAATACACATGGCAGCTAAGGCACAACGTCACGTTCTACGACGCCCTTTACGTCGCACTGGCCACCGC
ACTGGATGTCCCGCTGCTCACGGGCGACTCGCGGCTTGCGGCCGCGCCGGGCCTTCCGTGCGAAATCAAACTCGTTCGGT
GA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8176.54 Da
• Isoelectric Point: 4.9678

>AT198195 WP_211430004.1 NZ_CP072649:636990-637214 [Chloracidobacterium validum]
MSNLLERITVNPGQCGGRPCIRGMRIRVSDVLDLFAAGLSSEQILEELPDLEMDDLRAVLVYASRKLNHPVLVA

Nucleotide

• Length: 225 bp

>AT198195 NZ_CP096843:71281-71520 [Mycobacterium tuberculosis variant bovis]
ATGGCTACCATTCAAGTTCGGGATTTGCCCGAAGATGTCGCCGAAACCTATCGACGGCGCGCCACCGCAGCGGGGCAGTC
GCTGCAGACGTATATGCGCACCAAGCTCATCGAAGGGGTGCGGGGCCGAGACAAGGCCGAGGTAATCGAGATCCTGGAAC
AGGCGCTCGCCAGCACTGCCAGCCCAGGCATCAGCCGGGAGACCATCGAGGCATCCCGGCGGGAGCTCAGGGGTGGATGA