Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2111908..2112578 Replicon chromosome
Accession NZ_CP072648
Organism Chloracidobacterium validum strain BV2-C

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J8C06_RS08835 Protein ID WP_211428344.1
Coordinates 2112159..2112578 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J8C06_RS08830 Protein ID WP_211428343.1
Coordinates 2111908..2112162 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8C06_RS08820 (J8C06_08820) 2108991..2109824 - 834 WP_211428341.1 hypothetical protein -
J8C06_RS08825 (J8C06_08825) 2110007..2111551 + 1545 WP_211428342.1 glutamine-hydrolyzing GMP synthase -
J8C06_RS08830 (J8C06_08830) 2111908..2112162 + 255 WP_211428343.1 plasmid stabilization protein Antitoxin
J8C06_RS08835 (J8C06_08835) 2112159..2112578 + 420 WP_211428344.1 type II toxin-antitoxin system VapC family toxin Toxin
J8C06_RS08840 (J8C06_08840) 2112810..2114708 - 1899 WP_246602015.1 restriction endonuclease subunit R -
J8C06_RS15190 2114684..2115472 - 789 WP_246602016.1 DEAD/DEAH box helicase family protein -
J8C06_RS08845 (J8C06_08845) 2115741..2116187 - 447 WP_246602017.1 Zeta toxin family protein -
J8C06_RS08850 (J8C06_08850) 2116199..2116693 - 495 WP_246602018.1 hypothetical protein -
J8C06_RS15195 2116651..2116908 - 258 WP_246602019.1 DNA methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14749.78 Da        Isoelectric Point: 4.4857

>T198194 WP_211428344.1 NZ_CP072648:2112159-2112578 [Chloracidobacterium validum]
MIVLDTNVVSEAMKPEPNAAVMAFLNDQAAETLYISSVTVAELLFGIQALPQGRRRNMLDGALNDLLELFKDRVLPFDTD
AARHYAELAVAARNGGRGFPTPDGYIAAIAASRGFSVASRDTAPFEAVGVAVINPWGGA

Download         Length: 420 bp

>T198194 NZ_CP096842:3781357-3781767 [Mycobacterium tuberculosis variant bovis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9257.55 Da        Isoelectric Point: 6.4724

>AT198194 WP_211428343.1 NZ_CP072648:2111908-2112162 [Chloracidobacterium validum]
MAVLTIRNVPEDVHQALRVRAAQHGRSTEAEVREILAAAVKPENRVRVGDALAAIGRKIGLTEEDFAVLESIRDKTTAEP
PRFE

Download         Length: 255 bp

>AT198194 NZ_CP096842:3781082-3781360 [Mycobacterium tuberculosis variant bovis]
GTGGAGGCAATCGGAATCCGAGAACTAAGACAGCACGCATCGCGATACCTCGCCCGGGTTGAAGCCGGCGAGGAACTTGG
CGTCACCAACAAAGGAAGACTTGTGGCCCGACTCATCCCGGTGCAGGCCGCGGAGCGTTCTCGCGAAGCCCTGATTGAAT
CAGGTGTCCTGATTCCGGCTCGTCGTCCACAAAACCTTCTCGACGTCACCGCCGAACCGGCGCGCGGCCGCAAGCGCACC
CTGTCCGATGTTCTCAACGAAATGCGCGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References