Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 614626..615214 Replicon chromosome
Accession NZ_CP072647
Organism Chloracidobacterium sp. MS 40/45

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag J8C02_RS13515 Protein ID WP_246604689.1
Coordinates 614626..614967 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag J8C02_RS13520 Protein ID WP_211427109.1
Coordinates 614972..615214 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8C02_RS13495 (J8C02_13495) 610160..610744 - 585 WP_211427104.1 aminodeoxychorismate/anthranilate synthase component II -
J8C02_RS13500 (J8C02_13500) 610791..612257 - 1467 WP_211427105.1 anthranilate synthase component I family protein -
J8C02_RS13505 (J8C02_13505) 612254..613084 - 831 WP_211427106.1 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase -
J8C02_RS13510 (J8C02_13510) 613309..614382 - 1074 WP_211427107.1 lipopolysaccharide heptosyltransferase II -
J8C02_RS13515 (J8C02_13515) 614626..614967 - 342 WP_246604689.1 endoribonuclease MazF Toxin
J8C02_RS13520 (J8C02_13520) 614972..615214 - 243 WP_211427109.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J8C02_RS13525 (J8C02_13525) 615327..617252 - 1926 WP_211427110.1 CocE/NonD family hydrolase -
J8C02_RS13530 (J8C02_13530) 617322..617843 - 522 WP_211427111.1 adenine phosphoribosyltransferase -
J8C02_RS13535 (J8C02_13535) 618096..618374 - 279 WP_211427112.1 acylphosphatase -
J8C02_RS13545 (J8C02_13545) 618645..619121 - 477 WP_211427113.1 DUF4157 domain-containing protein -
J8C02_RS13550 (J8C02_13550) 619140..619676 - 537 WP_211423641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12569.81 Da        Isoelectric Point: 10.0153

>T198193 WP_246604689.1 NZ_CP072647:c614967-614626 [Chloracidobacterium sp. MS 40/45]
MAYVPDSGDIVWIMFTPQAGHEQAGRRPALVLSPKSYNSKVGLALLCPITSQVKGYPFEVLIPEGLKVKGAILSDQVKSL
DWKARKAELSCKLPKEKFNEVVRKLGTLIREQF

Download         Length: 342 bp

>T198193 NZ_CP096842:3727341-3727598 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8711.03 Da        Isoelectric Point: 4.3010

>AT198193 WP_211427109.1 NZ_CP072647:c615214-614972 [Chloracidobacterium sp. MS 40/45]
MLTKIQKWGNSLALRIPKVFAAEAQLQNDSLVEISIVEGKIIITPAPAPSWTLDELLAGITKDNLHPEVETGFAVGDEAW

Download         Length: 243 bp

>AT198193 NZ_CP096842:3727069-3727344 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References