Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 661872..662305 Replicon chromosome
Accession NZ_CP072635
Organism Chloracidobacterium sp. D

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J8C01_RS13950 Protein ID WP_211432825.1
Coordinates 662081..662305 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J8C01_RS13945 Protein ID WP_211432824.1
Coordinates 661872..662084 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8C01_RS13905 (J8C01_13905) 656947..657483 + 537 WP_211432821.1 hypothetical protein -
J8C01_RS13910 (J8C01_13910) 657502..657978 + 477 WP_014100927.1 DUF4157 domain-containing protein -
J8C01_RS13920 (J8C01_13920) 658247..658525 + 279 WP_014100926.1 acylphosphatase -
J8C01_RS13925 (J8C01_13925) 658792..659313 + 522 WP_014100925.1 adenine phosphoribosyltransferase -
J8C01_RS13930 (J8C01_13930) 659389..661314 + 1926 WP_249355504.1 CocE/NonD family hydrolase -
J8C01_RS13935 (J8C01_13935) 661427..661669 + 243 WP_211427109.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
J8C01_RS13940 (J8C01_13940) 661656..661820 + 165 Protein_542 type II toxin-antitoxin system PemK/MazF family toxin -
J8C01_RS13945 (J8C01_13945) 661872..662084 + 213 WP_211432824.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J8C01_RS13950 (J8C01_13950) 662081..662305 + 225 WP_211432825.1 type II toxin-antitoxin system HicA family toxin Toxin
J8C01_RS13955 (J8C01_13955) 663957..665030 + 1074 WP_211432826.1 lipopolysaccharide heptosyltransferase II -
J8C01_RS13960 (J8C01_13960) 665253..666083 + 831 WP_211432827.1 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8517.96 Da        Isoelectric Point: 10.2015

>T198192 WP_211432825.1 NZ_CP072635:662081-662305 [Chloracidobacterium sp. D]
VSDLPKISGRELVKALKKIGYEQDRQRGSHIILRQIDPPHRRVTVPDHKEIAKGTLWTIIREIGLTIDELKDLL

Download         Length: 225 bp

>T198192 NZ_CP096842:c3665363-3664935 [Mycobacterium tuberculosis variant bovis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7634.57 Da        Isoelectric Point: 4.2258

>AT198192 WP_211432824.1 NZ_CP072635:661872-662084 [Chloracidobacterium sp. D]
MKYRVFIEQDEDNVYVATAPSLPGCVSQGKTRSEALENIKEAITGYLESLKAHGEPVPPPISEEIVDVSS

Download         Length: 213 bp

>AT198192 NZ_CP096842:c3665609-3665367 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References