Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2289828..2290264 Replicon chromosome
Accession NZ_CP072634
Organism Chloracidobacterium sp. D

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J8C01_RS09700 Protein ID WP_211431773.1
Coordinates 2290040..2290264 (+) Length 75 a.a.

Antitoxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J8C01_RS09695 Protein ID WP_211432717.1
Coordinates 2289828..2290043 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8C01_RS09670 (J8C01_09670) 2285013..2285309 - 297 WP_211431769.1 hypothetical protein -
J8C01_RS09675 (J8C01_09675) 2285765..2286421 - 657 WP_211431770.1 formylglycine-generating enzyme family protein -
J8C01_RS09680 (J8C01_09680) 2286710..2287288 + 579 WP_014100447.1 thioredoxin family protein -
J8C01_RS09685 (J8C01_09685) 2287360..2288016 + 657 WP_211431771.1 riboflavin synthase -
J8C01_RS09690 (J8C01_09690) 2288034..2289482 - 1449 WP_211431772.1 pitrilysin family protein -
J8C01_RS09695 (J8C01_09695) 2289828..2290043 + 216 WP_211432717.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J8C01_RS09700 (J8C01_09700) 2290040..2290264 + 225 WP_211431773.1 type II toxin-antitoxin system HicA family toxin Toxin
J8C01_RS09705 (J8C01_09705) 2290505..2292346 + 1842 WP_211431774.1 ABC transporter ATP-binding protein -
J8C01_RS09710 (J8C01_09710) 2292394..2294004 + 1611 WP_249355441.1 murein biosynthesis integral membrane protein MurJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-54)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8197.68 Da        Isoelectric Point: 9.4492

>T198191 WP_211431773.1 NZ_CP072634:2290040-2290264 [Chloracidobacterium sp. D]
MTKLPRVKGQELIAALHKAGFDVVRIKGSHHFLRHSDGRCTVIPVHRGETIGPGLMSKILRDCEITSEALLELL

Download         Length: 225 bp

>T198191 NZ_CP096842:3510447-3510791 [Mycobacterium tuberculosis variant bovis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8278.44 Da        Isoelectric Point: 4.8171

>AT198191 WP_211432717.1 NZ_CP072634:2289828-2290043 [Chloracidobacterium sp. D]
MQREFSVIIERDPEGYYVASVPELRGCHTQAKSLDTLMKRVREAIELCLEVEGEHTSRQEFVGIQRVWVEV

Download         Length: 216 bp

>AT198191 NZ_CP096842:3510788-3511117 [Mycobacterium tuberculosis variant bovis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References