Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 257285..257718 | Replicon | chromosome |
| Accession | NZ_CP072633 | ||
| Organism | Chloracidobacterium thermophilum strain B | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | J8C08_RS12805 | Protein ID | WP_081464911.1 |
| Coordinates | 257285..257509 (-) | Length | 75 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | J8C08_RS12810 | Protein ID | WP_081464912.1 |
| Coordinates | 257506..257718 (-) | Length | 71 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8C08_RS12780 (J8C08_12780) | 252799..253434 | - | 636 | WP_228374105.1 | aminodeoxychorismate/anthranilate synthase component II | - |
| J8C08_RS12785 (J8C08_12785) | 253409..254896 | - | 1488 | WP_014100920.1 | anthranilate synthase component I family protein | - |
| J8C08_RS12790 (J8C08_12790) | 254893..255723 | - | 831 | WP_041569955.1 | bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase | - |
| J8C08_RS16795 (J8C08_12795) | 255946..256284 | - | 339 | WP_283248820.1 | glycosyltransferase family 9 protein | - |
| J8C08_RS12800 (J8C08_12800) | 256167..257018 | - | 852 | WP_212770440.1 | glycosyltransferase family 9 protein | - |
| J8C08_RS12805 (J8C08_12805) | 257285..257509 | - | 225 | WP_081464911.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| J8C08_RS12810 (J8C08_12810) | 257506..257718 | - | 213 | WP_081464912.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| J8C08_RS12815 (J8C08_12815) | 257770..257934 | - | 165 | Protein_227 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| J8C08_RS12820 (J8C08_12820) | 257921..258163 | - | 243 | WP_014100923.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | - |
| J8C08_RS16515 | 258276..258560 | - | 285 | WP_249399296.1 | CocE/NonD family hydrolase C-terminal non-catalytic domain-containing protein | - |
| J8C08_RS12825 (J8C08_12825) | 258674..260014 | - | 1341 | Protein_230 | CocE/NonD family hydrolase | - |
| J8C08_RS12830 (J8C08_12830) | 260276..260797 | - | 522 | WP_014100925.1 | adenine phosphoribosyltransferase | - |
| J8C08_RS12835 (J8C08_12835) | 261064..261342 | - | 279 | WP_014100926.1 | acylphosphatase | - |
| J8C08_RS12845 (J8C08_12845) | 261611..261814 | - | 204 | WP_212770441.1 | DUF4157 domain-containing protein | - |
| J8C08_RS12850 (J8C08_12850) | 261790..262086 | - | 297 | WP_212770442.1 | hypothetical protein | - |
| J8C08_RS12855 (J8C08_12855) | 262105..262641 | - | 537 | WP_014100928.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 230664..258163 | 27499 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 75 a.a. Molecular weight: 8487.93 Da Isoelectric Point: 10.4689
>T198190 WP_081464911.1 NZ_CP072633:c257509-257285 [Chloracidobacterium thermophilum]
VSDLPKISGRELVKALKKIGYEQDRQRGSHIILRQIDPPHRRVTVPDHKEIAKGTLRTIIREIGLTIDELKDLL
VSDLPKISGRELVKALKKIGYEQDRQRGSHIILRQIDPPHRRVTVPDHKEIAKGTLRTIIREIGLTIDELKDLL
Download Length: 225 bp
>T198190 NZ_CP096842:3142345-3142788 [Mycobacterium tuberculosis variant bovis]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA
Antitoxin
Download Length: 71 a.a. Molecular weight: 7646.62 Da Isoelectric Point: 4.2258
>AT198190 WP_081464912.1 NZ_CP072633:c257718-257506 [Chloracidobacterium thermophilum]
MKYRVFIEQDEDNVYIATVPSLPGCVSQGKTRSEALENIKEAIAGYLESLKAHGEPVPPPISEEIVDVSS
MKYRVFIEQDEDNVYIATVPSLPGCVSQGKTRSEALENIKEAIAGYLESLKAHGEPVPPPISEEIVDVSS
Download Length: 213 bp
>AT198190 NZ_CP096842:3142101-3142358 [Mycobacterium tuberculosis variant bovis]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|