Detailed information of TA system TA198189

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 230926..231359
• Replicon: chromosome
• Accession: NZ_CP072633
• Organism: Chloracidobacterium thermophilum strain B

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J8C08_RS12615
• Protein ID: WP_081464911.1
• Coordinates: 230926..231150 (-)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J8C08_RS12620
• Protein ID: WP_081464912.1
• Coordinates: 231147..231359 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8C08_RS12600 (J8C08_12600)	226440..228536	-	2097	WP_212770423.1	chorismate-binding protein	-
J8C08_RS12605 (J8C08_12605)	228533..229363	-	831	WP_041569955.1	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase	-
J8C08_RS12610 (J8C08_12610)	229586..230659	-	1074	WP_014100922.1	lipopolysaccharide heptosyltransferase II	-
J8C08_RS12615 (J8C08_12615)	230926..231150	-	225	WP_081464911.1	type II toxin-antitoxin system HicA family toxin	Toxin
J8C08_RS12620 (J8C08_12620)	231147..231359	-	213	WP_081464912.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J8C08_RS12625 (J8C08_12625)	231411..231575	-	165	Protein_186	type II toxin-antitoxin system PemK/MazF family toxin	-
J8C08_RS12630 (J8C08_12630)	231562..231804	-	243	WP_014100923.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
J8C08_RS12635 (J8C08_12635)	231917..233656	-	1740	WP_249399278.1	CocE/NonD family hydrolase	-
J8C08_RS12640 (J8C08_12640)	233917..234438	-	522	WP_014100925.1	adenine phosphoribosyltransferase	-
J8C08_RS12645 (J8C08_12645)	234705..234983	-	279	WP_014100926.1	acylphosphatase	-
J8C08_RS12655 (J8C08_12655)	235252..235728	-	477	WP_014100927.1	DUF4157 domain-containing protein	-
J8C08_RS12660 (J8C08_12660)	235747..236283	-	537	WP_014100928.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	230664..258163	27499

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (9-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-62)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8487.93 Da
• Isoelectric Point: 10.4689

>T198189 WP_081464911.1 NZ_CP072633:c231150-230926 [Chloracidobacterium thermophilum]
VSDLPKISGRELVKALKKIGYEQDRQRGSHIILRQIDPPHRRVTVPDHKEIAKGTLRTIIREIGLTIDELKDLL

Nucleotide

• Length: 225 bp

>T198189 NZ_CP096842:3136785-3137048 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7646.62 Da
• Isoelectric Point: 4.2258

>AT198189 WP_081464912.1 NZ_CP072633:c231359-231147 [Chloracidobacterium thermophilum]
MKYRVFIEQDEDNVYIATVPSLPGCVSQGKTRSEALENIKEAIAGYLESLKAHGEPVPPPISEEIVDVSS

Nucleotide

• Length: 213 bp

>AT198189 NZ_CP096842:3136500-3136781 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA