Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2467755..2468383 Replicon chromosome
Accession NZ_CP072630
Organism Leptospira borgpetersenii strain FMAS_AP2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH590_RS10495 Protein ID WP_002736113.1
Coordinates 2467982..2468383 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH590_RS10490 Protein ID WP_010705987.1
Coordinates 2467755..2467985 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH590_RS10480 (FH590_10480) 2465728..2466426 - 699 WP_002724172.1 hypothetical protein -
FH590_RS17175 2466609..2466837 - 229 Protein_2075 hypothetical protein -
FH590_RS10485 (FH590_10485) 2467352..2467489 - 138 WP_002736206.1 hypothetical protein -
FH590_RS10490 (FH590_10490) 2467755..2467985 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH590_RS10495 (FH590_10495) 2467982..2468383 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH590_RS10500 (FH590_10500) 2468529..2468708 - 180 WP_002724268.1 hypothetical protein -
FH590_RS10505 (FH590_10505) 2468818..2470500 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH590_RS10510 (FH590_10510) 2470909..2471453 + 545 Protein_2081 metal-dependent hydrolase -
FH590_RS10515 (FH590_10515) 2472246..2472536 + 291 WP_002736220.1 YciI family protein -
FH590_RS10520 (FH590_10520) 2472545..2473241 - 697 Protein_2083 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198188 WP_002736113.1 NZ_CP072630:2467982-2468383 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198188 NZ_CP096842:c3096029-3095637 [Mycobacterium tuberculosis variant bovis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGGCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198188 WP_010705987.1 NZ_CP072630:2467755-2467985 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198188 NZ_CP096842:c3096241-3096026 [Mycobacterium tuberculosis variant bovis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References