Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 479938..480503 Replicon chromosome
Accession NZ_CP072630
Organism Leptospira borgpetersenii strain FMAS_AP2

Toxin (Protein)


Gene name mazF Uniprot ID V6I350
Locus tag FH590_RS02060 Protein ID WP_002753850.1
Coordinates 479938..480186 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FH590_RS02065 Protein ID WP_011670965.1
Coordinates 480180..480503 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH590_RS02040 (FH590_02040) 474986..475987 + 1002 WP_002732926.1 metallophosphoesterase -
FH590_RS02045 (FH590_02045) 475990..476667 + 678 WP_002725755.1 hypothetical protein -
FH590_RS02050 (FH590_02050) 476664..477080 + 417 WP_118883418.1 hypothetical protein -
FH590_RS02055 (FH590_02055) 477061..479241 + 2181 WP_002732919.1 ATP-dependent DNA helicase RecG -
FH590_RS02060 (FH590_02060) 479938..480186 + 249 WP_002753850.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
FH590_RS02065 (FH590_02065) 480180..480503 + 324 WP_011670965.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
FH590_RS02070 (FH590_02070) 480939..482474 + 1536 WP_002738394.1 phosphomethylpyrimidine synthase ThiC -
FH590_RS02075 (FH590_02075) 482850..483506 + 657 Protein_411 helicase-related protein -
FH590_RS02080 (FH590_02080) 483881..484225 - 345 WP_002728323.1 TIGR04452 family lipoprotein -
FH590_RS02085 (FH590_02085) 484558..485301 + 744 WP_002728313.1 M15 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(6-49)

Antitoxin

mRNA interferase PemK-like

(5-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9459.00 Da        Isoelectric Point: 5.1749

>T198186 WP_002753850.1 NZ_CP072630:479938-480186 [Leptospira borgpetersenii]
MKALVVKIGNSKGIRIPKAVLEECHIEEEVDLLIDNNKLIIVPLKSKPREGWEKQFKSMSSNKDDKLLIPDSIDLSDKDW
EW

Download         Length: 249 bp

>T198186 NZ_CP096842:c3069074-3068718 [Mycobacterium tuberculosis variant bovis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12296.80 Da        Isoelectric Point: 10.5161

>AT198186 WP_011670965.1 NZ_CP072630:480180-480503 [Leptospira borgpetersenii]
MVISQYEVYLINLDPTVGHEIKKSRPCVIISPNEMNKTIGTIIITPMTTKSRSYPTRVELTFQGKKGWIVLDQIRTVDKI
RLIKKLGKIDPKTVNKMKLIIKEMLVD

Download         Length: 324 bp

>AT198186 NZ_CP096842:c3069288-3069058 [Mycobacterium tuberculosis variant bovis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6I350

Antitoxin

Source ID Structure

References