198185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2468169..2468797 Replicon chromosome
Accession NZ_CP072628
Organism Leptospira borgpetersenii strain FMAS_AP3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH591_RS10470 Protein ID WP_002736113.1
Coordinates 2468396..2468797 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH591_RS10465 Protein ID WP_010705987.1
Coordinates 2468169..2468399 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH591_RS10455 (FH591_10455) 2466142..2466840 - 699 WP_002724172.1 hypothetical protein -
FH591_RS17145 2467023..2467251 - 229 Protein_2067 hypothetical protein -
FH591_RS10460 (FH591_10460) 2467766..2467903 - 138 WP_002736206.1 hypothetical protein -
FH591_RS10465 (FH591_10465) 2468169..2468399 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH591_RS10470 (FH591_10470) 2468396..2468797 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH591_RS10475 (FH591_10475) 2468943..2469122 - 180 WP_002724268.1 hypothetical protein -
FH591_RS10480 (FH591_10480) 2469232..2470914 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH591_RS10485 (FH591_10485) 2471323..2471867 + 545 Protein_2073 metal-dependent hydrolase -
FH591_RS10490 (FH591_10490) 2472660..2472950 + 291 WP_002736220.1 YciI family protein -
FH591_RS10495 (FH591_10495) 2472959..2473655 - 697 Protein_2075 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198185 WP_002736113.1 NZ_CP072628:2468396-2468797 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198185 NZ_CP096842:c3029822-3029427 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198185 WP_010705987.1 NZ_CP072628:2468169-2468399 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198185 NZ_CP096842:c3029401-3029135 [Mycobacterium tuberculosis variant bovis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References