Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2468165..2468793 Replicon chromosome
Accession NZ_CP072626
Organism Leptospira borgpetersenii strain FMAS_AP4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH592_RS10500 Protein ID WP_002736113.1
Coordinates 2468392..2468793 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH592_RS10495 Protein ID WP_010705987.1
Coordinates 2468165..2468395 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH592_RS10485 (FH592_10460) 2466138..2466836 - 699 WP_002724172.1 hypothetical protein -
FH592_RS17180 2467019..2467247 - 229 Protein_2076 hypothetical protein -
FH592_RS10490 (FH592_10465) 2467762..2467899 - 138 WP_002736206.1 hypothetical protein -
FH592_RS10495 (FH592_10470) 2468165..2468395 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH592_RS10500 (FH592_10475) 2468392..2468793 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH592_RS10505 (FH592_10480) 2468939..2469118 - 180 WP_002724268.1 hypothetical protein -
FH592_RS10510 (FH592_10485) 2469228..2470910 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH592_RS10515 (FH592_10490) 2471319..2471863 + 545 Protein_2082 metal-dependent hydrolase -
FH592_RS10520 (FH592_10500) 2472656..2472946 + 291 WP_002736220.1 YciI family protein -
FH592_RS10525 (FH592_10505) 2472955..2473651 - 697 Protein_2084 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198182 WP_002736113.1 NZ_CP072626:2468392-2468793 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198182 NZ_CP096842:c2839613-2839218 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198182 WP_010705987.1 NZ_CP072626:2468165-2468395 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198182 NZ_CP096842:c2839855-2839610 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References