Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2468629..2469257 Replicon chromosome
Accession NZ_CP072624
Organism Leptospira borgpetersenii strain FMAS_PN1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH596_RS10495 Protein ID WP_002736113.1
Coordinates 2468856..2469257 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH596_RS10490 Protein ID WP_010705987.1
Coordinates 2468629..2468859 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH596_RS10480 (FH596_10480) 2466602..2467300 - 699 WP_002724172.1 hypothetical protein -
FH596_RS17195 2467483..2467711 - 229 Protein_2076 hypothetical protein -
FH596_RS10485 (FH596_10485) 2468226..2468363 - 138 WP_002736206.1 hypothetical protein -
FH596_RS10490 (FH596_10490) 2468629..2468859 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH596_RS10495 (FH596_10495) 2468856..2469257 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH596_RS10500 (FH596_10500) 2469403..2469582 - 180 WP_002724268.1 hypothetical protein -
FH596_RS10505 (FH596_10505) 2469692..2471374 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH596_RS10510 (FH596_10510) 2471783..2472327 + 545 Protein_2082 metal-dependent hydrolase -
FH596_RS10515 (FH596_10515) 2473120..2473410 + 291 WP_002736220.1 YciI family protein -
FH596_RS10520 (FH596_10520) 2473419..2474115 - 697 Protein_2084 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198179 WP_002736113.1 NZ_CP072624:2468856-2469257 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198179 NZ_CP096842:c2823521-2823102 [Mycobacterium tuberculosis variant bovis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198179 WP_010705987.1 NZ_CP072624:2468629-2468859 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198179 NZ_CP096842:c2823742-2823518 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References