Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2468217..2468845 Replicon chromosome
Accession NZ_CP072622
Organism Leptospira borgpetersenii strain FMAS_PN4

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH599_RS10485 Protein ID WP_002736113.1
Coordinates 2468444..2468845 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH599_RS10480 Protein ID WP_010705987.1
Coordinates 2468217..2468447 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH599_RS10470 (FH599_10470) 2466190..2466888 - 699 WP_002724172.1 hypothetical protein -
FH599_RS17170 2467071..2467299 - 229 Protein_2075 hypothetical protein -
FH599_RS10475 (FH599_10475) 2467814..2467951 - 138 WP_002736206.1 hypothetical protein -
FH599_RS10480 (FH599_10480) 2468217..2468447 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH599_RS10485 (FH599_10485) 2468444..2468845 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH599_RS10490 (FH599_10490) 2468991..2469170 - 180 WP_002724268.1 hypothetical protein -
FH599_RS10495 (FH599_10495) 2469280..2470961 - 1682 Protein_2080 dihydroxy-acid dehydratase -
FH599_RS10500 (FH599_10500) 2471370..2471914 + 545 Protein_2081 metal-dependent hydrolase -
FH599_RS10505 (FH599_10505) 2472707..2472997 + 291 WP_002736220.1 YciI family protein -
FH599_RS10510 (FH599_10510) 2473006..2473702 - 697 Protein_2083 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198176 WP_002736113.1 NZ_CP072622:2468444-2468845 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198176 NZ_CP096842:c2350931-2350497 [Mycobacterium tuberculosis variant bovis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198176 WP_010705987.1 NZ_CP072622:2468217-2468447 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198176 NZ_CP096842:c2351192-2350938 [Mycobacterium tuberculosis variant bovis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References