Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2468242..2468870 Replicon chromosome
Accession NZ_CP072620
Organism Leptospira borgpetersenii strain FMAS_AP8

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH600_RS10490 Protein ID WP_002736113.1
Coordinates 2468469..2468870 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH600_RS10485 Protein ID WP_010705987.1
Coordinates 2468242..2468472 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH600_RS10475 (FH600_10475) 2466215..2466913 - 699 WP_002724172.1 hypothetical protein -
FH600_RS17175 2467096..2467324 - 229 Protein_2074 hypothetical protein -
FH600_RS10480 (FH600_10480) 2467839..2467976 - 138 WP_002736206.1 hypothetical protein -
FH600_RS10485 (FH600_10485) 2468242..2468472 + 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH600_RS10490 (FH600_10490) 2468469..2468870 + 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH600_RS10495 (FH600_10495) 2469016..2469195 - 180 WP_002724268.1 hypothetical protein -
FH600_RS10500 (FH600_10500) 2469305..2470987 - 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH600_RS10505 (FH600_10505) 2471396..2471940 + 545 Protein_2080 metal-dependent hydrolase -
FH600_RS10510 (FH600_10510) 2472733..2473023 + 291 WP_002736220.1 YciI family protein -
FH600_RS10515 (FH600_10515) 2473032..2473728 - 697 Protein_2082 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198173 WP_002736113.1 NZ_CP072620:2468469-2468870 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198173 NZ_CP096842:c2218130-2217786 [Mycobacterium tuberculosis variant bovis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198173 WP_010705987.1 NZ_CP072620:2468242-2468472 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198173 NZ_CP096842:c2218372-2218124 [Mycobacterium tuberculosis variant bovis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References