Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 841427..842055 Replicon chromosome
Accession NZ_CP072618
Organism Leptospira borgpetersenii strain FMAS_AP9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FH601_RS03745 Protein ID WP_002736113.1
Coordinates 841427..841828 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FH601_RS03750 Protein ID WP_010705987.1
Coordinates 841825..842055 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FH601_RS03720 (FH601_03720) 836569..837265 + 697 Protein_729 adenylate/guanylate cyclase domain-containing protein -
FH601_RS03725 (FH601_03725) 837274..837564 - 291 WP_002736220.1 YciI family protein -
FH601_RS03730 (FH601_03730) 838357..838901 - 545 Protein_731 metal-dependent hydrolase -
FH601_RS03735 (FH601_03735) 839310..840992 + 1683 WP_002724258.1 dihydroxy-acid dehydratase -
FH601_RS03740 (FH601_03740) 841102..841281 + 180 WP_002724268.1 hypothetical protein -
FH601_RS03745 (FH601_03745) 841427..841828 - 402 WP_002736113.1 type II toxin-antitoxin system VapC family toxin Toxin
FH601_RS03750 (FH601_03750) 841825..842055 - 231 WP_010705987.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
FH601_RS03755 (FH601_03755) 842252..842458 + 207 WP_268766581.1 IS3 family transposase -
FH601_RS17020 842973..843201 + 229 Protein_737 hypothetical protein -
FH601_RS03760 (FH601_03760) 843384..844082 + 699 WP_002724172.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15467.21 Da        Isoelectric Point: 9.9288

>T198168 WP_002736113.1 NZ_CP072618:c841828-841427 [Leptospira borgpetersenii]
MTQYLLDTNICIYIINQKPRSVYKKFKKIKLENIFISSITEFELKYGVQKSLHLERNLKILEEFLSYLNILSFVSEDANK
AAKIRVELDKVGKPIGPFDLLIASQALSNKLTLVTNNEKEFTRIKDIKIANWL

Download         Length: 402 bp

>T198168 NZ_CP096842:c2191172-2190843 [Mycobacterium tuberculosis variant bovis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8947.11 Da        Isoelectric Point: 10.1326

>AT198168 WP_010705987.1 NZ_CP072618:c842055-841825 [Leptospira borgpetersenii]
MNKAKIFKNGDSQAIRLPKDYRFKGKEVYIRRDGDNVILTPINDAVDRFWNTVNSFSDDLILDRNQPNEYGKRNKI

Download         Length: 231 bp

>AT198168 NZ_CP096842:c2191546-2191169 [Mycobacterium tuberculosis variant bovis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References