Detailed information of TA system TA198167

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 97429..97990
• Replicon: plasmid pSpoCB-3
• Accession: NZ_CP072616
• Organism: Sulfitobacter sp. CB2047

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8E2S910
• Locus tag: IV89_RS18165
• Protein ID: WP_037945150.1
• Coordinates: 97715..97990 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8E2SB59
• Locus tag: IV89_RS18160
• Protein ID: WP_037945151.1
• Coordinates: 97429..97722 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IV89_RS18145 (IV89_003632)	94045..96027	+	1983	WP_037945155.1	ParB/RepB/Spo0J family partition protein	-
IV89_RS18150 (IV89_003633)	96111..96704	+	594	WP_037945154.1	hypothetical protein	-
IV89_RS18155 (IV89_003634)	96704..97360	+	657	WP_037945153.1	hypothetical protein	-
IV89_RS18160 (IV89_003635)	97429..97722	+	294	WP_037945151.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IV89_RS18165 (IV89_003636)	97715..97990	+	276	WP_037945150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IV89_RS18170 (IV89_003637)	98103..102365	+	4263	WP_037945149.1	strawberry notch family protein	-
IV89_RS18175 (IV89_003638)	102476..102691	+	216	WP_037945148.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..130875	130875

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-68)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10297.73 Da
• Isoelectric Point: 4.4275

>T198167 WP_037945150.1 NZ_CP072616:97715-97990 [Sulfitobacter sp. CB2047]
VPDLEWKATAIADLLAIIDYISDDNPDAAQALKDEIEVKTSRLPEHPQMYRVGRVDGTREMVVRPNYIVIYADDPSSIVI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T198167 NZ_CP096842:1958125-1958373 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10372.78 Da
• Isoelectric Point: 5.0162

>AT198167 WP_037945151.1 NZ_CP072616:97429-97722 [Sulfitobacter sp. CB2047]
MPAQTSMIHVRVDDQLKAQALDALSGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRSKVQEALDDSKPTTPQ
AQAMQDAQALIDKKRRA

Nucleotide

• Length: 294 bp

>AT198167 NZ_CP096842:1957913-1958125 [Mycobacterium tuberculosis variant bovis]
ATGGAATTGGCGGCTCGAATGGGCGAGACTTTGACACAAGCGGTCGTAGTTGCAGTGCGGGAGCAACTGGCCCGCCGGAC
CGGGCGCACCAGATCCATTTCGCTACGCGAGGAGTTGGCCGCCATTGGCCGGCGCTGCGCGGCCTTACCGGTGCTCGACA
CCCGAGCCGCGGACACGATTCTCGGCTACGACGAGCGCGGGTTGCCCGCCTGA