Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 2527696..2528207 Replicon chromosome
Accession NZ_CP072608
Organism Desulfovibrio desulfuricans strain L4

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag J8J02_RS10870 Protein ID WP_209817888.1
Coordinates 2527947..2528207 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag J8J02_RS10865 Protein ID WP_209817886.1
Coordinates 2527696..2527944 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8J02_RS10850 (J8J02_10850) 2523088..2524056 - 969 WP_096152589.1 IS30 family transposase -
J8J02_RS10855 (J8J02_10855) 2524270..2527011 - 2742 WP_209817882.1 DUF927 domain-containing protein -
J8J02_RS10860 (J8J02_10860) 2527175..2527405 - 231 WP_209817884.1 hypothetical protein -
J8J02_RS10865 (J8J02_10865) 2527696..2527944 + 249 WP_209817886.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
J8J02_RS10870 (J8J02_10870) 2527947..2528207 + 261 WP_209817888.1 Txe/YoeB family addiction module toxin Toxin
J8J02_RS10875 (J8J02_10875) 2528878..2530302 - 1425 WP_022657535.1 sodium:solute symporter family protein -
J8J02_RS10880 (J8J02_10880) 2530536..2531783 - 1248 WP_209817890.1 Glu/Leu/Phe/Val dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2478242..2528690 50448


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10483.03 Da        Isoelectric Point: 8.7028

>T198157 WP_209817888.1 NZ_CP072608:2527947-2528207 [Desulfovibrio desulfuricans]
MLLTWTPQAWEDYCYWQQVDRKKLKRINELIRDAMRSPSDGLGKPEALRFDLTGCWSRRIDHEHRLVYKVDSERNALIIV
QCRYHY

Download         Length: 261 bp

>T198157 NZ_CP096842:1167981-1168862 [Mycobacterium tuberculosis variant bovis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9088.22 Da        Isoelectric Point: 4.6965

>AT198157 WP_209817886.1 NZ_CP072608:2527696-2527944 [Desulfovibrio desulfuricans]
MPEAITYSDARQNLAATMDRVCDAHEPVIITRQKSQSVVMISLEDYSGLMETAHLLRSPANAQRLRDSLASCSSVEQHDL
VD

Download         Length: 249 bp

>AT198157 NZ_CP096842:1167361-1167984 [Mycobacterium tuberculosis variant bovis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References