Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 39389..40038 Replicon plasmid pAU0505
Accession NZ_CP072603
Organism Burkholderia latens strain AU0505

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J8I85_RS25905 Protein ID WP_011695140.1
Coordinates 39389..39799 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J8I85_RS25910 Protein ID WP_080330903.1
Coordinates 39796..40038 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I85_RS25850 (J8I85_25850) 34423..34671 - 249 WP_209822868.1 hypothetical protein -
J8I85_RS25855 (J8I85_25855) 34675..35085 - 411 WP_209822834.1 hypothetical protein -
J8I85_RS25860 (J8I85_25860) 35082..35384 - 303 WP_209822835.1 hypothetical protein -
J8I85_RS25865 (J8I85_25865) 35381..35572 - 192 WP_209822836.1 hypothetical protein -
J8I85_RS25870 (J8I85_25870) 35590..36303 - 714 WP_209822837.1 hypothetical protein -
J8I85_RS25875 (J8I85_25875) 36310..36558 - 249 WP_209822838.1 hypothetical protein -
J8I85_RS25880 (J8I85_25880) 36588..36995 - 408 WP_209822839.1 hypothetical protein -
J8I85_RS25885 (J8I85_25885) 37029..37769 - 741 WP_245163741.1 hypothetical protein -
J8I85_RS25890 (J8I85_25890) 38253..38570 - 318 WP_245163742.1 hypothetical protein -
J8I85_RS25895 (J8I85_25895) 38730..39083 - 354 WP_245163747.1 hypothetical protein -
J8I85_RS25900 (J8I85_25900) 39168..39308 - 141 WP_209822841.1 hypothetical protein -
J8I85_RS25905 (J8I85_25905) 39389..39799 - 411 WP_011695140.1 type II toxin-antitoxin system VapC family toxin Toxin
J8I85_RS25910 (J8I85_25910) 39796..40038 - 243 WP_080330903.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
J8I85_RS25915 (J8I85_25915) 40160..41128 - 969 WP_245163743.1 non-homologous end-joining DNA ligase -
J8I85_RS25920 (J8I85_25920) 41272..42072 - 801 Protein_52 ISNCY family transposase -
J8I85_RS25925 (J8I85_25925) 42071..42400 + 330 WP_209822843.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..59003 59003
- flank IS/Tn - - 44833..45093 260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(12-50)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14773.00 Da        Isoelectric Point: 5.1526

>T198149 WP_011695140.1 NZ_CP072603:c39799-39389 [Burkholderia latens]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIVVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVAGLPVENWLRSAT

Download         Length: 411 bp

>T198149 NZ_CP096842:717645-718040 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9320.60 Da        Isoelectric Point: 4.8499

>AT198149 WP_080330903.1 NZ_CP072603:c40038-39796 [Burkholderia latens]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAAPLRELFAQWTPLDETFPDIVDLPPEPVDIE

Download         Length: 243 bp

>AT198149 NZ_CP096842:717391-717645 [Mycobacterium tuberculosis variant bovis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References