Detailed information of TA system TA198148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 1461592..1462838
• Replicon: chromosome
• Accession: NZ_CP072602
• Organism: Burkholderia latens strain AU0505

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: J8I85_RS21590
• Protein ID: WP_209821882.1
• Coordinates: 1462257..1462838 (+)
• Length: 194 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: J8I85_RS21585
• Protein ID: WP_209821881.1
• Coordinates: 1461592..1462149 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I85_RS21560 (J8I85_21560)	1456659..1457213	-	555	WP_209821876.1	YrhB domain-containing protein	-
J8I85_RS21565 (J8I85_21565)	1457364..1457837	-	474	WP_209821877.1	cupin domain-containing protein	-
J8I85_RS21570 (J8I85_21570)	1458206..1458841	+	636	WP_209821878.1	isochorismatase family cysteine hydrolase	-
J8I85_RS21575 (J8I85_21575)	1458926..1459657	-	732	WP_209821879.1	ribonuclease T2	-
J8I85_RS21580 (J8I85_21580)	1459862..1461265	-	1404	WP_209821880.1	DUF308 domain-containing protein	-
J8I85_RS21585 (J8I85_21585)	1461592..1462149	+	558	WP_209821881.1	helix-turn-helix transcriptional regulator	Antitoxin
J8I85_RS21590 (J8I85_21590)	1462257..1462838	+	582	WP_209821882.1	HD domain-containing protein	Toxin
J8I85_RS21595 (J8I85_21595)	1462966..1463082	+	117	Protein_1319	SAM-dependent methyltransferase	-
J8I85_RS21600 (J8I85_21600)	1463094..1464632	-	1539	WP_209821883.1	MFS transporter	-
J8I85_RS21605 (J8I85_21605)	1464819..1465754	+	936	WP_059544434.1	LysR family transcriptional regulator	-
J8I85_RS21610 (J8I85_21610)	1465797..1466936	-	1140	WP_059544435.1	enoyl-CoA hydratase/isomerase family protein	-
J8I85_RS21615 (J8I85_21615)	1466933..1467724	-	792	WP_059544437.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-169)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-61)

Sequences

Toxin

Protein

• Length: 194 a.a.
• Molecular weight: 21386.98 Da
• Isoelectric Point: 4.8451

>T198148 WP_209821882.1 NZ_CP072602:1462257-1462838 [Burkholderia latens]
MKLDTIHARLDFLRDAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAVSPEARAAKALDKLETIMQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDTRDDGA

Nucleotide

• Length: 582 bp

>T198148 NZ_CP096842:711987-712388 [Mycobacterium tuberculosis variant bovis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20306.40 Da
• Isoelectric Point: 10.2102

>AT198148 WP_209821881.1 NZ_CP072602:1461592-1462149 [Burkholderia latens]
MCASPLHTPPLGPQLKRWRTLHRMKQSHAAELFGVAQSTISRWEAGIQQMSADERAMAERLLAARLDSAGDRALARLIES
STSRMHLVCDLTHRLLASSPSRAAEFSRPLATLLGTSLWRYASPEIVRMEAALDPLGWRDCAGPPSVEFATGANASRIVP
IRGSTCRWTRMMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT198148 NZ_CP096842:711763-711990 [Mycobacterium tuberculosis variant bovis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA