Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1181612..1183362 Replicon chromosome
Accession NZ_CP072602
Organism Burkholderia latens strain AU0505

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag J8I85_RS20365 Protein ID WP_209822741.1
Coordinates 1182466..1183362 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag J8I85_RS20360 Protein ID WP_209822740.1
Coordinates 1181612..1182469 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I85_RS20340 (J8I85_20340) 1176751..1178241 - 1491 WP_040140229.1 aldehyde dehydrogenase -
J8I85_RS20345 (J8I85_20345) 1178323..1179162 - 840 WP_209822738.1 aspartate dehydrogenase -
J8I85_RS20350 (J8I85_20350) 1179155..1180825 - 1671 WP_209822739.1 thiamine pyrophosphate-binding protein -
J8I85_RS20355 (J8I85_20355) 1180818..1181615 - 798 WP_069243121.1 SDR family oxidoreductase -
J8I85_RS20360 (J8I85_20360) 1181612..1182469 - 858 WP_209822740.1 IclR family transcriptional regulator Antitoxin
J8I85_RS20365 (J8I85_20365) 1182466..1183362 - 897 WP_209822741.1 alpha/beta fold hydrolase Toxin
J8I85_RS20370 (J8I85_20370) 1183381..1183908 - 528 WP_040140236.1 cupin domain-containing protein -
J8I85_RS20375 (J8I85_20375) 1183943..1184713 - 771 WP_040140237.1 SDR family oxidoreductase -
J8I85_RS20380 (J8I85_20380) 1184706..1185776 - 1071 WP_059547330.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
J8I85_RS20385 (J8I85_20385) 1185837..1186148 - 312 WP_059547333.1 hypothetical protein -
J8I85_RS20390 (J8I85_20390) 1186150..1186467 - 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
J8I85_RS20395 (J8I85_20395) 1186915..1187994 + 1080 WP_209822742.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30745.00 Da        Isoelectric Point: 8.0700

>T198147 WP_209822741.1 NZ_CP072602:c1183362-1182466 [Burkholderia latens]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGATGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGASTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLARVMPARIAGLLLISPAGGYGSAPAETR
DTRRDARLAMLAELGPAGLAEQRSGNMLSGFAGEEARAWVRWNMARIVPAGYAQATHLLANADLASDLAGFRGSTAVAVG
AHDAITPPAACERIAAAAHVKLQVIPQAGHAGYVEAPAVYSSLIDAFCRQCDRQRGLE

Download         Length: 897 bp

>T198147 NZ_CP096842:704467-704868 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31151.55 Da        Isoelectric Point: 6.0503

>AT198147 WP_209822740.1 NZ_CP072602:c1182469-1181612 [Burkholderia latens]
MSEPLERQDTENAKSEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGGDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLAELRALYPEGTLNQMTSATPATVDALYEAIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT198147 NZ_CP096842:704225-704470 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References