Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 85680..86321 Replicon chromosome
Accession NZ_CP072602
Organism Burkholderia latens strain AU0505

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J8I85_RS15420 Protein ID WP_040139283.1
Coordinates 85983..86321 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag J8I85_RS15415 Protein ID WP_006756590.1
Coordinates 85680..85979 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I85_RS15390 (J8I85_15390) 80869..82140 + 1272 WP_040139278.1 anthranilate 1,2-dioxygenase large subunit AndAc -
J8I85_RS15395 (J8I85_15395) 82158..82643 + 486 WP_040139279.1 anthranilate 1,2-dioxygenase small subunit AndAd -
J8I85_RS15400 (J8I85_15400) 82670..82996 + 327 WP_040139280.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
J8I85_RS15405 (J8I85_15405) 82986..84206 + 1221 WP_069242686.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
J8I85_RS15410 (J8I85_15410) 84359..85645 + 1287 WP_209822256.1 DUF445 domain-containing protein -
J8I85_RS15415 (J8I85_15415) 85680..85979 - 300 WP_006756590.1 putative addiction module antidote protein Antitoxin
J8I85_RS15420 (J8I85_15420) 85983..86321 - 339 WP_040139283.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8I85_RS15425 (J8I85_15425) 86693..88333 + 1641 WP_040139284.1 acetolactate synthase large subunit -
J8I85_RS15430 (J8I85_15430) 88363..89796 + 1434 WP_069242689.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-103)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12747.57 Da        Isoelectric Point: 8.8952

>T198146 WP_040139283.1 NZ_CP072602:c86321-85983 [Burkholderia latens]
MVDILKSMPYSSPSYSIRTTDAFDAWFAALTDRVARRRIQARIDRLSMGNPGDWKSAGSPIVEMRIDHGPGYRVYYARRE
TIWVILLCGGDKSTQQADIRAAHAMLERLDLE

Download         Length: 339 bp

>T198146 NZ_CP096842:c698548-698135 [Mycobacterium tuberculosis variant bovis]
GTGAAACCGCCGCTGGCAGTGGACACCAGCGTCGCGATTCCGTTGCTGGTACGGACCCATACCGCGCATGCGGCGGTTGT
CGCCTGGTGGGCACATCGGGAGGCCGCGCTGTGCGGGCACGCCCTGGCCGAAACCTACTCCGTGCTGACCCGCCTGCCGC
GTGACCTACGACTGGCACCGATGGACGCCGCGCGGCTTCTTACCGAACGCTTTGCGGCACCGCTGTTGTTGAGTTCCCGC
ACCACTGAACATCTCCCACGCGTGCTGGCCCAATTCGAGATCACTGGTGGCGCGGTCTATGACGCTCTCGTGGCCCTTGC
CGCCGCCGAGCACCGGGCTGAACTCGCCACACGCGATGCTCGAGCCAAGGACACTTACGAAAAGATCGGCGTCCACGTCG
TTGTCGCCGCGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10688.13 Da        Isoelectric Point: 6.6387

>AT198146 WP_006756590.1 NZ_CP072602:c85979-85680 [Burkholderia latens]
MDKIKTRPWDSAEHLKTDDDMAEYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT198146 NZ_CP096842:c698781-698545 [Mycobacterium tuberculosis variant bovis]
ATGAAGGCTGTTGTGGATGCGGCTGGCCGCATCGTCGTACCCAAACCGCTGCGCGAAGCCTTGGGGCTGCAACCGGGGTC
CACCGTGGAAATATCCCGCTATGGCGCTGGTCTCCACCTGATTCCCACCGGACGAACAGCGCGTCTCGAAGAGGAGAATG
GCGTACTGGTGGCCACCGGTGAGACCACGATCGACGATGAGGTCGTGTTCGGCCTTATCGATAGCGGCCGGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References