Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 607085..607568 Replicon chromosome
Accession NZ_CP072600
Organism Leptothermofonsia sichuanensis PKUAC-SCTE412

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J5X98_RS02650 Protein ID WP_223048635.1
Coordinates 607085..607354 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J5X98_RS02655 Protein ID WP_223048636.1
Coordinates 607335..607568 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5X98_RS02625 (J5X98_02625) 603324..604295 - 972 WP_223048631.1 AraC family transcriptional regulator -
J5X98_RS02630 (J5X98_02630) 604423..605112 + 690 WP_239033265.1 Uma2 family endonuclease -
J5X98_RS02635 (J5X98_02635) 605255..605530 + 276 WP_223048632.1 BrnT family toxin -
J5X98_RS02640 (J5X98_02640) 605550..605792 + 243 WP_223048633.1 BrnA antitoxin family protein -
J5X98_RS02645 (J5X98_02645) 605794..606966 - 1173 WP_223048634.1 PepSY-associated TM helix domain-containing protein -
J5X98_RS02650 (J5X98_02650) 607085..607354 + 270 WP_223048635.1 BrnT family toxin Toxin
J5X98_RS02655 (J5X98_02655) 607335..607568 + 234 WP_223048636.1 BrnA antitoxin family protein Antitoxin
J5X98_RS02660 (J5X98_02660) 607617..610187 - 2571 WP_223048637.1 TonB-dependent siderophore receptor -
J5X98_RS02665 (J5X98_02665) 610705..611367 + 663 WP_225938303.1 MotA/TolQ/ExbB proton channel family protein -
J5X98_RS02670 (J5X98_02670) 611345..611752 + 408 WP_223048638.1 biopolymer transporter ExbD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-80)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10654.03 Da        Isoelectric Point: 5.6631

>T198144 WP_223048635.1 NZ_CP072600:607085-607354 [Leptothermofonsia sichuanensis PKUAC-SCTE412]
MEFEFDPHKSQLNQEKHGIDFWEAQQLWADVNRIEIPARTEDEVRFLVIGKIISKHWSAVITYREGRVRVISVRRSRPEE
IEIYESNSI

Download         Length: 270 bp

>T198144 NZ_CP096842:678902-679309 [Mycobacterium tuberculosis variant bovis]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8765.88 Da        Isoelectric Point: 4.4091

>AT198144 WP_223048636.1 NZ_CP072600:607335-607568 [Leptothermofonsia sichuanensis PKUAC-SCTE412]
MKATAFDQRFDQGDDVSELLDLSAARRPGYESQTVAIDFPEWMLNGLDREARRLGVSRDALVKVWLAERLEQLPLTS

Download         Length: 234 bp

>AT198144 NZ_CP096842:678690-678905 [Mycobacterium tuberculosis variant bovis]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References