Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Hha-TomB/- |
| Location | 2731342..2731967 | Replicon | chromosome |
| Accession | NZ_CP072598 | ||
| Organism | Duffyella gerundensis isolate A4 | ||
Toxin (Protein)
| Gene name | Hha | Uniprot ID | A0A0U5L254 |
| Locus tag | J8I88_RS12575 | Protein ID | WP_067428457.1 |
| Coordinates | 2731749..2731967 (+) | Length | 73 a.a. |
Antitoxin (Protein)
| Gene name | TomB | Uniprot ID | - |
| Locus tag | J8I88_RS12570 | Protein ID | WP_067428460.1 |
| Coordinates | 2731342..2731716 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8I88_RS12540 (J8I88_12540) | 2727603..2727860 | + | 258 | WP_067428465.1 | type B 50S ribosomal protein L31 | - |
| J8I88_RS12545 (J8I88_12545) | 2727870..2728010 | + | 141 | WP_071852488.1 | type B 50S ribosomal protein L36 | - |
| J8I88_RS12550 (J8I88_12550) | 2728085..2728963 | - | 879 | WP_067428464.1 | metal ABC transporter substrate-binding protein | - |
| J8I88_RS12555 (J8I88_12555) | 2728980..2729819 | - | 840 | WP_209502280.1 | metal ABC transporter permease | - |
| J8I88_RS12560 (J8I88_12560) | 2729816..2730493 | - | 678 | WP_209500398.1 | ABC transporter ATP-binding protein | - |
| J8I88_RS12565 (J8I88_12565) | 2730840..2731193 | + | 354 | WP_067428462.1 | hypothetical protein | - |
| J8I88_RS12570 (J8I88_12570) | 2731342..2731716 | + | 375 | WP_067428460.1 | Hha toxicity modulator TomB | Antitoxin |
| J8I88_RS12575 (J8I88_12575) | 2731749..2731967 | + | 219 | WP_067428457.1 | HHA domain-containing protein | Toxin |
| J8I88_RS12585 (J8I88_12585) | 2732334..2732648 | + | 315 | WP_233702273.1 | MGMT family protein | - |
| J8I88_RS12590 (J8I88_12590) | 2732674..2733231 | - | 558 | WP_067435173.1 | YbaY family lipoprotein | - |
| J8I88_RS12595 (J8I88_12595) | 2733422..2734285 | + | 864 | WP_067435170.1 | acyl-CoA thioesterase II | - |
| J8I88_RS12600 (J8I88_12600) | 2734347..2735636 | - | 1290 | WP_067435167.1 | ammonium transporter AmtB | - |
| J8I88_RS12605 (J8I88_12605) | 2735666..2736004 | - | 339 | WP_067428451.1 | P-II family nitrogen regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8640.06 Da Isoelectric Point: 9.4825
>T198143 WP_067428457.1 NZ_CP072598:2731749-2731967 [Duffyella gerundensis]
MSDKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDNELAIFYSAADHRLAELTMNKLYDKVPVSVWKFVR
MSDKTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDNELAIFYSAADHRLAELTMNKLYDKVPVSVWKFVR
Download Length: 219 bp
>T198143 NZ_CP096842:c445636-445043 [Mycobacterium tuberculosis variant bovis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14474.08 Da Isoelectric Point: 4.5014
>AT198143 WP_067428460.1 NZ_CP072598:2731342-2731716 [Duffyella gerundensis]
MDEYSPKRHDMAQLKYLCESLHDDSMATLSDSHHGWVNDPTSASNLQLNDLIEHIASFTMNYKIKHVEDEELITQIDEYL
DDTFMLFSNYGVSAQDLQRWQRSAKRLFNIFAEECALLQPSHSF
MDEYSPKRHDMAQLKYLCESLHDDSMATLSDSHHGWVNDPTSASNLQLNDLIEHIASFTMNYKIKHVEDEELITQIDEYL
DDTFMLFSNYGVSAQDLQRWQRSAKRLFNIFAEECALLQPSHSF
Download Length: 375 bp
>AT198143 NZ_CP096842:c446054-445665 [Mycobacterium tuberculosis variant bovis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|