Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 1851387..1852297 Replicon chromosome
Accession NZ_CP072598
Organism Duffyella gerundensis isolate A4

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag J8I88_RS08355 Protein ID WP_209502119.1
Coordinates 1851387..1851857 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag J8I88_RS08360 Protein ID WP_209502121.1
Coordinates 1851854..1852297 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I88_RS08340 (J8I88_08340) 1846964..1848454 - 1491 WP_209502116.1 PLP-dependent aminotransferase family protein -
J8I88_RS08345 (J8I88_08345) 1848563..1849849 + 1287 WP_209502118.1 4-aminobutyrate--2-oxoglutarate transaminase -
J8I88_RS08350 (J8I88_08350) 1849928..1851334 + 1407 WP_187485939.1 GABA permease -
J8I88_RS08355 (J8I88_08355) 1851387..1851857 - 471 WP_209502119.1 RES family NAD+ phosphorylase Toxin
J8I88_RS08360 (J8I88_08360) 1851854..1852297 - 444 WP_209502121.1 DUF2384 domain-containing protein Antitoxin
J8I88_RS08365 (J8I88_08365) 1852820..1854028 + 1209 WP_209502123.1 YcaO-like family protein -
J8I88_RS08370 (J8I88_08370) 1854034..1854864 + 831 WP_209502124.1 class I SAM-dependent methyltransferase -
J8I88_RS08375 (J8I88_08375) 1854898..1855695 - 798 WP_067430508.1 SIR2 family protein -
J8I88_RS08380 (J8I88_08380) 1855695..1856252 - 558 WP_067430506.1 non-canonical purine NTP pyrophosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(94-144)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17146.38 Da        Isoelectric Point: 5.5353

>T198142 WP_209502119.1 NZ_CP072598:c1851857-1851387 [Duffyella gerundensis]
VKLYRLTKTRYLSSAWSGYGAREGGGRWNNVGVSMVYASETASLTMLEILVHLQSAATLDAYTLLCVEVPDGLIQWIDVT
QLPENWRAAEAPAALREIGDAWISSGESVALRIPSALSPVEHNFLLNPDHPAFTEQVSRASHIPFMFDSRFGTAHS

Download         Length: 471 bp

>T198142 NZ_CP096842:364996-365421 [Mycobacterium tuberculosis variant bovis]
GTGACTGACCAGCGCTGGCTGATCGACAAGTCGGCGCTGGTGCGGCTCACGGACAGCCCTGACATGGAAATCTGGTCGAA
CCGGATCGAACGCGGCCTGGTACACATCACGGGCGTGACACGCTTGGAAGTAGGGTTCTCGGCCGAATGCGGGGAGATAG
CGCGACGGGAGTTTCGTGAACCGCCGCTGTCTGCGATGCCCGTGGAATACCTAACCCCGAGAATTGAAGACCGTGCGCTC
GAGGTGCAGACCTTGCTTGCCGACCGCGGACACCACCGTGGCCCGTCGATCCCGGATCTGCTCATCGCCGCGACAGCCGA
ACTGTCGGGCTTGACGGTACTGCACGTCGACAAGGACTTTGACGCCATCGCCGCGCTTACCGGTCAGAAAACAGAACGGC
TCACGCATCGCCCGCCTTCCGCTTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16627.05 Da        Isoelectric Point: 9.6528

>AT198142 WP_209502121.1 NZ_CP072598:c1852297-1851854 [Duffyella gerundensis]
MKQFTLPARHHSPERLWQVAGLNSADGVMLMGQIDRGLEGAVANRIISWALMTQADLRHVTGIPATTFNRGMKDRFTAEQ
SERLVRFIRVMDRAVELFEGDKHKAQQWLNEPARALDNKKPADLVSSETGAYEVLKLITRLEHGVYS

Download         Length: 444 bp

>AT198142 NZ_CP096842:364778-364999 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References