Detailed information of TA system TA198141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1547082..1547674
• Replicon: chromosome
• Accession: NZ_CP072598
• Organism: Duffyella gerundensis isolate A4

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: J8I88_RS06930
• Protein ID: WP_209501949.1
• Coordinates: 1547082..1547336 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: J8I88_RS06935
• Protein ID: WP_209501951.1
• Coordinates: 1547333..1547674 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J8I88_RS06910 (J8I88_06910)	1543304..1543684	+	381	WP_209501942.1	VOC family protein	-
J8I88_RS06915 (J8I88_06915)	1543977..1544534	-	558	WP_209501944.1	hypothetical protein	-
J8I88_RS06920 (J8I88_06920)	1544691..1545197	+	507	WP_209501945.1	hypothetical protein	-
J8I88_RS06930 (J8I88_06930)	1547082..1547336	+	255	WP_209501949.1	type II toxin-antitoxin system HicA family toxin	Toxin
J8I88_RS06935 (J8I88_06935)	1547333..1547674	+	342	WP_209501951.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
J8I88_RS06940 (J8I88_06940)	1547745..1548662	+	918	WP_209501953.1	nucleotide-binding protein	-
J8I88_RS06945 (J8I88_06945)	1548711..1549349	-	639	Protein_1341	phage portal protein	-
J8I88_RS20505	1549914..1550045	-	132	WP_262385462.1	hypothetical protein	-
J8I88_RS06950 (J8I88_06950)	1550067..1550714	+	648	WP_067431266.1	metallophosphoesterase	-
J8I88_RS06955 (J8I88_06955)	1550716..1552152	-	1437	WP_187486064.1	16S rRNA (cytosine(1407)-C(5))-methyltransferase RsmF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-77)

Antitoxin

• Uncharacterised protein family HicB (55-100)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9352.80 Da
• Isoelectric Point: 11.3704

>T198141 WP_209501949.1 NZ_CP072598:1547082-1547336 [Duffyella gerundensis]
MNKRHQKTLSDVFARPVSGSIKWSDIESLFIALGAAVHEREGSRIAVLLKGQKKIFHSPHSRPTTDKGAVNSIRVWLDSL
GMRS

Nucleotide

• Length: 255 bp

>T198141 NZ_CP096842:364428-364730 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12562.18 Da
• Isoelectric Point: 4.6132

>AT198141 WP_209501951.1 NZ_CP072598:1547333-1547674 [Duffyella gerundensis]
MNNTLKIDGHLAVITFDPEIEMFRGEFVGLNGGADFYAYSVEELKKEGSTSLAVFLDECRKDDIEPYKTFSGKVTTRLTP
ERHQALAITAQAHGVSINELLNEGVDLVIEKRS

Nucleotide

• Length: 342 bp

>AT198141 NZ_CP096842:364778-364999 [Mycobacterium tuberculosis variant bovis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA