Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1480107..1480642 Replicon chromosome
Accession NZ_CP072598
Organism Duffyella gerundensis isolate A4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J8I88_RS06605 Protein ID WP_209501907.1
Coordinates 1480107..1480394 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag J8I88_RS06610 Protein ID WP_209501908.1
Coordinates 1480400..1480642 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8I88_RS06585 (J8I88_06585) 1475664..1476743 + 1080 WP_187486089.1 two-component system sensor histidine kinase PmrB -
J8I88_RS06590 (J8I88_06590) 1477045..1477452 + 408 WP_209501895.1 S24 family peptidase -
J8I88_RS06595 (J8I88_06595) 1477670..1478344 + 675 WP_209501897.1 hypothetical protein -
J8I88_RS06600 (J8I88_06600) 1478819..1480078 + 1260 WP_209501905.1 translesion error-prone DNA polymerase V subunit UmuC -
J8I88_RS06605 (J8I88_06605) 1480107..1480394 - 288 WP_209501907.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J8I88_RS06610 (J8I88_06610) 1480400..1480642 - 243 WP_209501908.1 antitoxin Antitoxin
J8I88_RS06615 (J8I88_06615) 1481317..1482110 + 794 Protein_1274 trehalose-phosphatase -
J8I88_RS06620 (J8I88_06620) 1482107..1483543 + 1437 WP_209501910.1 alpha,alpha-trehalose-phosphate synthase -
J8I88_RS06625 (J8I88_06625) 1484610..1484966 + 357 WP_209502222.1 flagellar transcriptional regulator FlhD -
J8I88_RS06630 (J8I88_06630) 1484963..1485541 + 579 WP_209501912.1 flagellar transcriptional regulator FlhC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10974.00 Da        Isoelectric Point: 10.5498

>T198140 WP_209501907.1 NZ_CP072598:c1480394-1480107 [Duffyella gerundensis]
MGYTIKIREEALKEWNGLDSIIREQFKKKLKKPLENPHIPAARLSGMPDCYKIKLRASGFRLVYQVMDDVLIVAVVAVGK
RERSQAYKLASERLR

Download         Length: 288 bp

>T198140 NZ_CP096842:364428-364730 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8798.17 Da        Isoelectric Point: 4.1789

>AT198140 WP_209501908.1 NZ_CP072598:c1480642-1480400 [Duffyella gerundensis]
MANLILSDTSASVSELKKNPMATVEAGAGMPVAILNRNQPVFYCVPAHLYEKMLEIIDDQELATLVKARENQPLLDLDLD

Download         Length: 243 bp

>AT198140 NZ_CP096842:364204-364431 [Mycobacterium tuberculosis variant bovis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References