Detailed information of TA system TA198137

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2936778..2937329
• Replicon: chromosome
• Accession: NZ_CP072596
• Organism: Tessaracoccus sp. MC1865

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: J7D54_RS13645
• Protein ID: WP_182763178.1
• Coordinates: 2936778..2937092 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: J7D54_RS13650
• Protein ID: WP_182763177.1
• Coordinates: 2937096..2937329 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7D54_RS13620 (J7D54_13620)	2932278..2933645	+	1368	WP_182763183.1	6-phospho-beta-glucosidase	-
J7D54_RS13625 (J7D54_13625)	2933709..2934587	-	879	WP_182763182.1	fructose bisphosphate aldolase	-
J7D54_RS13630 (J7D54_13630)	2934686..2935420	-	735	WP_182763181.1	phosphatase PAP2 family protein	-
J7D54_RS13635 (J7D54_13635)	2935461..2935889	-	429	WP_182763180.1	deaminase	-
J7D54_RS13640 (J7D54_13640)	2936213..2936653	+	441	WP_182763179.1	alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB	-
J7D54_RS13645 (J7D54_13645)	2936778..2937092	-	315	WP_182763178.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
J7D54_RS13650 (J7D54_13650)	2937096..2937329	-	234	WP_182763177.1	YlcI/YnfO family protein	Antitoxin
J7D54_RS13655 (J7D54_13655)	2937392..2937661	-	270	WP_182763176.1	type II toxin-antitoxin system RelE/ParE family toxin	-
J7D54_RS13660 (J7D54_13660)	2937658..2937939	-	282	WP_209455152.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
J7D54_RS13665 (J7D54_13665)	2938030..2938290	+	261	WP_182763175.1	hypothetical protein	-
J7D54_RS13670 (J7D54_13670)	2938351..2939376	-	1026	WP_182763174.1	beta-propeller fold lactonase family protein	-
J7D54_RS13675 (J7D54_13675)	2939425..2941284	-	1860	WP_182763173.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-95)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11020.88 Da
• Isoelectric Point: 6.9767

>T198137 WP_182763178.1 NZ_CP072596:c2937092-2936778 [Tessaracoccus sp. MC1865]
VREICLVRLDKTRPAVVLTRAAARAAMTKVTIAPITSTIKGLSSEVPVGPANGLDHDGVISLDNVVTVPSRLLGRTVGFL
TYAQEAELARAVVLAYDLDIPLLD

Nucleotide

• Length: 315 bp

>T198137 NZ_CP096841:c3749075-3748683 [Mycobacterium tuberculosis variant bovis]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8500.59 Da
• Isoelectric Point: 4.5837

>AT198137 WP_182763177.1 NZ_CP072596:c2937329-2937096 [Tessaracoccus sp. MC1865]
MTVQIAIRLPDDMVAFLDKSVAAGNAPSRAALVARAVEREMRRQVAEHDAAILRERGTTDELDELVNWSVAHTTVED

Nucleotide

• Length: 234 bp

>AT198137 NZ_CP096841:c3749350-3749075 [Mycobacterium tuberculosis variant bovis]
ATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGAGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATACGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA