Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3630371..3632069 Replicon chromosome
Accession NZ_CP072566
Organism Escherichia coli strain WG5::TT12A

Toxin (Protein)


Gene name mosT Uniprot ID A0A3Y1KBU9
Locus tag J8F85_RS17525 Protein ID WP_047085429.1
Coordinates 3630371..3631300 (-) Length 310 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag J8F85_RS17530 Protein ID WP_172808160.1
Coordinates 3631287..3632069 (-) Length 261 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8F85_RS17500 (3625799) 3625799..3627307 + 1509 WP_032206693.1 group II intron reverse transcriptase/maturase -
J8F85_RS17505 (3627391) 3627391..3627870 + 480 Protein_3438 IS3 family transposase -
J8F85_RS17510 (3627909) 3627909..3628088 - 180 Protein_3439 hypothetical protein -
J8F85_RS17515 (3628254) 3628254..3628976 - 723 WP_081508859.1 SDR family oxidoreductase -
J8F85_RS17520 (3629075) 3629075..3629974 + 900 WP_000687182.1 LysR family transcriptional regulator -
J8F85_RS17525 (3630371) 3630371..3631300 - 930 WP_047085429.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
J8F85_RS17530 (3631287) 3631287..3632069 - 783 WP_172808160.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
J8F85_RS17535 (3632353) 3632353..3634020 + 1668 WP_236941917.1 type I restriction endonuclease -
J8F85_RS17540 (3634083) 3634083..3635245 + 1163 WP_085947598.1 IS3-like element IS3 family transposase -
J8F85_RS17545 (3635242) 3635242..3635541 - 300 WP_236941918.1 hypothetical protein -
J8F85_RS17550 (3635666) 3635666..3636363 + 698 WP_223293341.1 IS1-like element IS1B family transposase -
J8F85_RS17555 (3636380) 3636380..3636583 - 204 Protein_3448 DUF3987 domain-containing protein -
J8F85_RS17560 (3636642) 3636642..3636737 + 96 WP_211180486.1 putative translational regulatory protein ArgL -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3622641..3636363 13722


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 310 a.a.        Molecular weight: 34960.38 Da        Isoelectric Point: 7.3232

>T198113 WP_047085429.1 NZ_CP072566:c3631300-3630371 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNSK
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKRNSPDWSRYRYPEIQHLPAIRWKQRNLAVLKDKNPAKYVAAVSKLERVLEQYS

Download         Length: 930 bp

>T198113 NZ_CP096841:c2192990-2192694 [Mycobacterium tuberculosis variant bovis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin


Download         Length: 261 a.a.        Molecular weight: 29183.36 Da        Isoelectric Point: 8.5995

>AT198113 WP_172808160.1 NZ_CP072566:c3632069-3631287 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKSVRVAGLT
SLALQGHAHYTEPGRPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTPFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGSGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Download         Length: 783 bp

>AT198113 NZ_CP096841:c2193238-2192987 [Mycobacterium tuberculosis variant bovis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3Y1KBU9


Antitoxin

Source ID Structure

References