Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2268973..2269499 | Replicon | chromosome |
| Accession | NZ_CP072566 | ||
| Organism | Escherichia coli strain WG5::TT12A | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | J8F85_RS10850 | Protein ID | WP_047402633.1 |
| Coordinates | 2269212..2269499 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | J8F85_RS10845 | Protein ID | WP_000534858.1 |
| Coordinates | 2268973..2269212 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J8F85_RS10815 (2264077) | 2264077..2264498 | + | 422 | Protein_2124 | hypothetical protein | - |
| J8F85_RS10825 (2266379) | 2266379..2267401 | + | 1023 | Protein_2126 | ISNCY family transposase | - |
| J8F85_RS10830 (2267522) | 2267522..2267671 | + | 150 | WP_011443592.1 | protein YdfW | - |
| J8F85_RS10835 (2268108) | 2268108..2268440 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| J8F85_RS10840 (2268643) | 2268643..2268948 | - | 306 | WP_001326990.1 | protein YdfV | - |
| J8F85_RS10845 (2268973) | 2268973..2269212 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| J8F85_RS10850 (2269212) | 2269212..2269499 | + | 288 | WP_047402633.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| J8F85_RS10855 (2269571) | 2269571..2269726 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| J8F85_RS10860 (2269943) | 2269943..2270194 | + | 252 | WP_000980994.1 | protein Rem | - |
| J8F85_RS10865 (2270261) | 2270261..2270539 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| J8F85_RS10870 (2270541) | 2270541..2271590 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| J8F85_RS10875 (2271604) | 2271604..2272356 | + | 753 | WP_001047135.1 | antitermination protein | - |
| J8F85_RS10880 (2272634) | 2272634..2272723 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| J8F85_RS10885 (2272778) | 2272778..2272990 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| J8F85_RS10890 (2273291) | 2273291..2273506 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| J8F85_RS10895 (2273870) | 2273870..2274040 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| J8F85_RS10900 (2274260) | 2274260..2274475 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2256755..2290996 | 34241 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11224.28 Da Isoelectric Point: 10.4221
>T198109 WP_047402633.1 NZ_CP072566:2269212-2269499 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLKSPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLKSPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T198109 NZ_CP096841:c1930445-1930056 [Mycobacterium tuberculosis variant bovis]
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
GTGATCGTGTTGGACGCCTCGGCGGCCGTCGAGCTCATGCTCACGACGCCGGCGGGTGCGGCGGTCGCCCGGCGCTTGCG
GGGCGAAACCGTGCACGCCCCTGCACATTTCGATGTCGAGGTGATCGGGGCGATACGTCAAGCGGTCGTGCGTCAGCTGA
TCAGCGATCATGAAGGACTCGTCGTGGTTGTCAACTTCCTTAGCCTGCCCGTTCGGCGTTGGCCGTTAAAGCCATTCACC
CAGCGTGCCTACCAACTTCGGTCCACTCATACCGTGGCCGATGGAGCCTACGTCGCCCTCGCCGAGGGCCTCGGCGTACC
GCTTATCACTTGCGACGGGCGACTTGCCCAATCCCATGGCCATAATGCGGAGATCGAGCTTGTCGCCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT198109 WP_000534858.1 NZ_CP072566:2268973-2269212 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT198109 NZ_CP096841:c1930669-1930442 [Mycobacterium tuberculosis variant bovis]
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
ATGTCCGCCATGGTTCAGATCCGCAACGTTCCCGACGAGCTTCTCCACGAGCTGAAGGCCCGCGCAGCGGCGCAACGGAT
GAGCCTGAGCGATTTCCTCCTAGCACGGCTTGCCGAGATCGCGGAAGAACCGGCCCTCGACGACGTTCTCGACCGTCTAG
CGGCACTGCCGCGCCGGGATCTCGGCGCGAGCGCAGCCGAGCTTGTTGACGAGGCTCGATCTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 4FXE | |
| PDB | 2KC8 | |
| PDB | 2K29 | |
| AlphaFold DB | A0A4V1CTS8 |