Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2332531..2333057 Replicon chromosome
Accession NZ_CP072565
Organism Escherichia coli strain WG5::PA8

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag J8F86_RS11275 Protein ID WP_047402633.1
Coordinates 2332770..2333057 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag J8F86_RS11270 Protein ID WP_000534858.1
Coordinates 2332531..2332770 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8F86_RS11240 (2327635) 2327635..2328056 + 422 Protein_2206 hypothetical protein -
J8F86_RS11250 (2329937) 2329937..2330959 + 1023 Protein_2208 ISNCY family transposase -
J8F86_RS11255 (2331080) 2331080..2331229 + 150 WP_011443592.1 protein YdfW -
J8F86_RS11260 (2331666) 2331666..2331998 - 333 WP_001301033.1 FlxA-like family protein -
J8F86_RS11265 (2332201) 2332201..2332506 - 306 WP_001326990.1 protein YdfV -
J8F86_RS11270 (2332531) 2332531..2332770 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
J8F86_RS11275 (2332770) 2332770..2333057 + 288 WP_047402633.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
J8F86_RS11280 (2333129) 2333129..2333284 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
J8F86_RS11285 (2333501) 2333501..2333752 + 252 WP_000980994.1 protein Rem -
J8F86_RS11290 (2333819) 2333819..2334097 + 279 WP_012304870.1 hypothetical protein -
J8F86_RS11295 (2334099) 2334099..2335148 + 1050 WP_001265199.1 DUF968 domain-containing protein -
J8F86_RS11300 (2335162) 2335162..2335914 + 753 WP_001047135.1 antitermination protein -
J8F86_RS11305 (2336192) 2336192..2336281 - 90 WP_120795389.1 hypothetical protein -
J8F86_RS11310 (2336336) 2336336..2336548 - 213 WP_000087756.1 cold shock-like protein CspF -
J8F86_RS11315 (2336849) 2336849..2337064 + 216 WP_000066484.1 cold shock-like protein CspB -
J8F86_RS11320 (2337428) 2337428..2337598 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
J8F86_RS11325 (2337818) 2337818..2338033 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2320443..2354554 34111


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11224.28 Da        Isoelectric Point: 10.4221

>T198086 WP_047402633.1 NZ_CP072565:2332770-2333057 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLKSPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T198086 NZ_CP096841:c445671-445078 [Mycobacterium tuberculosis variant bovis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT198086 WP_000534858.1 NZ_CP072565:2332531-2332770 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT198086 NZ_CP096841:c446089-445700 [Mycobacterium tuberculosis variant bovis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References