Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4098090..4098685 Replicon chromosome
Accession NZ_CP072564
Organism Escherichia coli strain WG5::PA2

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag J8F87_RS19760 Protein ID WP_000239579.1
Coordinates 4098090..4098440 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A240D6C8
Locus tag J8F87_RS19765 Protein ID WP_001223212.1
Coordinates 4098434..4098685 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J8F87_RS19740 (4093536) 4093536..4094558 - 1023 WP_001355798.1 ABC transporter permease -
J8F87_RS19745 (4094572) 4094572..4096074 - 1503 WP_000210553.1 sugar ABC transporter ATP-binding protein -
J8F87_RS19750 (4096214) 4096214..4097170 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
J8F87_RS19755 (4097480) 4097480..4098010 + 531 WP_000055072.1 inorganic diphosphatase -
J8F87_RS19760 (4098090) 4098090..4098440 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
J8F87_RS19765 (4098434) 4098434..4098685 - 252 WP_001223212.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
J8F87_RS19770 (4098897) 4098897..4099238 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
J8F87_RS19775 (4099241) 4099241..4103020 - 3780 WP_000060921.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T198070 WP_000239579.1 NZ_CP072564:c4098440-4098090 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T198070 NZ_CP096840:c3028343-3027927 [Mycobacterium tuberculosis variant bovis]
ATGACCACGCGCTATTTGCTCGACAAATCAGCGGCTTACCGCGCGCACTTGCCCGCGGTCCGACATCGCTTGGAACCGTT
GATGGAACGCGGTCTACTGGCCCGGTGCGGCATTACCGATCTCGAGTTCGGAGTCTCGGCGCGTTCCCGCGAGGACCATC
GAACACTGGGCACCTACCGGCGTGACGCGCTCGAATACGTCAACACCCCCGACACCGTGTGGGTTCGTGCATGGGAGATC
CAAGAAGCATTGACCGACAAGGGATTTCACCGCTCGGTCAAGATCCCGGACTTGATCATTGCGGCGGTCGCCGAGCATCA
CGGCATACCCGTCATGCACTACGACCAAGACTTCGAACGCATCGCCGCCATCACACGGCAACCCGTGGAATGGGTGGTGG
CCCCAGGGACAGCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9301.61 Da        Isoelectric Point: 4.6509

>AT198070 WP_001223212.1 NZ_CP072564:c4098685-4098434 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT198070 NZ_CP096840:c3028606-3028340 [Mycobacterium tuberculosis variant bovis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A240D6C8

References