Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 2939487..2940180 | Replicon | chromosome |
| Accession | NZ_CP072559 | ||
| Organism | Pseudomonas sp. BYT-1 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | N2IHR9 |
| Locus tag | J5X93_RS13600 | Protein ID | WP_003151133.1 |
| Coordinates | 2939487..2939864 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | N2IIN5 |
| Locus tag | J5X93_RS13605 | Protein ID | WP_001172026.1 |
| Coordinates | 2939845..2940180 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J5X93_RS13585 (J5X93_13535) | 2934739..2935656 | + | 918 | Protein_2687 | Tn3 family transposase | - |
| J5X93_RS13590 (J5X93_13540) | 2935680..2938709 | - | 3030 | WP_010799689.1 | Tn3 family transposase | - |
| J5X93_RS13595 (J5X93_13545) | 2938693..2939295 | - | 603 | WP_010465829.1 | recombinase family protein | - |
| J5X93_RS13600 (J5X93_13550) | 2939487..2939864 | + | 378 | WP_003151133.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| J5X93_RS13605 (J5X93_13555) | 2939845..2940180 | + | 336 | WP_001172026.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| J5X93_RS13610 (J5X93_13560) | 2940195..2940530 | + | 336 | WP_000741275.1 | hypothetical protein | - |
| J5X93_RS13615 (J5X93_13565) | 2940554..2940880 | + | 327 | WP_000091614.1 | hypothetical protein | - |
| J5X93_RS13620 (J5X93_13570) | 2940896..2941237 | + | 342 | WP_025999701.1 | hypothetical protein | - |
| J5X93_RS13625 (J5X93_13575) | 2941278..2941568 | + | 291 | WP_004423344.1 | hypothetical protein | - |
| J5X93_RS13630 (J5X93_13580) | 2941565..2941909 | + | 345 | WP_004423345.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| J5X93_RS13635 (J5X93_13585) | 2942031..2943569 | + | 1539 | WP_011911868.1 | IS66 family transposase | - |
| J5X93_RS13640 (J5X93_13590) | 2943559..2943828 | + | 270 | WP_003458515.1 | hypothetical protein | - |
| J5X93_RS13645 (J5X93_13595) | 2944014..2944343 | - | 330 | WP_032489165.1 | four-helix bundle copper-binding protein | - |
| J5X93_RS13650 (J5X93_13600) | 2944536..2944622 | + | 87 | Protein_2700 | AAA family ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | pvdM / pvdO | 2734028..3275925 | 541897 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13705.78 Da Isoelectric Point: 9.4693
>T198045 WP_003151133.1 NZ_CP072559:2939487-2939864 [Pseudomonas sp. BYT-1]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKVLKGFGGAGVLEVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQELRNAKTNH
Download Length: 378 bp
>T198045 NZ_CP096840:1238310-1238684 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12201.39 Da Isoelectric Point: 10.6058
>AT198045 WP_001172026.1 NZ_CP072559:2939845-2940180 [Pseudomonas sp. BYT-1]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
Download Length: 336 bp
>AT198045 NZ_CP096840:1238116-1238313 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024ELN5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A024EKI7 |