Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3297871..3298525 Replicon chromosome
Accession NZ_CP072555
Organism Klebsiella pneumoniae strain KP2648

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag J7339_RS16315 Protein ID WP_004144731.1
Coordinates 3298118..3298525 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag J7339_RS16310 Protein ID WP_002916312.1
Coordinates 3297871..3298137 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7339_RS16285 (J7339_16230) 3293027..3294460 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
J7339_RS16290 (J7339_16235) 3294579..3295307 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
J7339_RS16295 (J7339_16240) 3295357..3295668 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
J7339_RS16300 (J7339_16245) 3295832..3296491 + 660 WP_002916317.1 hemolysin III family protein -
J7339_RS16305 (J7339_16250) 3296642..3297625 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
J7339_RS16310 (J7339_16255) 3297871..3298137 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
J7339_RS16315 (J7339_16260) 3298118..3298525 + 408 WP_004144731.1 protein YgfX Toxin
J7339_RS16320 (J7339_16265) 3298532..3299053 - 522 WP_002916308.1 flavodoxin FldB -
J7339_RS16325 (J7339_16270) 3299154..3300050 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
J7339_RS16330 (J7339_16275) 3300073..3300786 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
J7339_RS16335 (J7339_16280) 3300792..3302525 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T198026 WP_004144731.1 NZ_CP072555:3298118-3298525 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T198026 NZ_CP096840:361642-361944 [Mycobacterium tuberculosis variant bovis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT198026 WP_002916312.1 NZ_CP072555:3297871-3298137 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT198026 NZ_CP096840:361418-361645 [Mycobacterium tuberculosis variant bovis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References