Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1861691..1862207 Replicon chromosome
Accession NZ_CP072555
Organism Klebsiella pneumoniae strain KP2648

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag J7339_RS09225 Protein ID WP_002886902.1
Coordinates 1861691..1861975 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag J7339_RS09230 Protein ID WP_002886901.1
Coordinates 1861965..1862207 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7339_RS09200 (J7339_09145) 1857175..1857438 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
J7339_RS09205 (J7339_09150) 1857568..1857741 + 174 WP_002886906.1 hypothetical protein -
J7339_RS09210 (J7339_09155) 1857744..1858487 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
J7339_RS09215 (J7339_09160) 1858844..1860982 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
J7339_RS09220 (J7339_09165) 1861223..1861687 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
J7339_RS09225 (J7339_09170) 1861691..1861975 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
J7339_RS09230 (J7339_09175) 1861965..1862207 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
J7339_RS09235 (J7339_09180) 1862285..1864195 - 1911 WP_004152270.1 PRD domain-containing protein -
J7339_RS09240 (J7339_09185) 1864218..1865372 - 1155 WP_002886900.1 lactonase family protein -
J7339_RS09245 (J7339_09190) 1865438..1866178 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T198020 WP_002886902.1 NZ_CP072555:c1861975-1861691 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T198020 NZ_CP096839:3511905-3512249 [Mycobacterium tuberculosis variant bovis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT198020 WP_002886901.1 NZ_CP072555:c1862207-1861965 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT198020 NZ_CP096839:3512246-3512575 [Mycobacterium tuberculosis variant bovis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References