Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1143298..1143917 Replicon chromosome
Accession NZ_CP072555
Organism Klebsiella pneumoniae strain KP2648

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag J7339_RS05770 Protein ID WP_002892050.1
Coordinates 1143699..1143917 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag J7339_RS05765 Protein ID WP_002892066.1
Coordinates 1143298..1143672 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7339_RS05755 (J7339_05715) 1138450..1139643 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
J7339_RS05760 (J7339_05720) 1139666..1142812 + 3147 WP_200200657.1 multidrug efflux RND transporter permease subunit AcrB -
J7339_RS05765 (J7339_05725) 1143298..1143672 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
J7339_RS05770 (J7339_05730) 1143699..1143917 + 219 WP_002892050.1 HHA domain-containing protein Toxin
J7339_RS05775 (J7339_05735) 1144076..1144642 + 567 WP_002892030.1 maltose O-acetyltransferase -
J7339_RS05780 (J7339_05740) 1144614..1144754 - 141 WP_004147370.1 hypothetical protein -
J7339_RS05785 (J7339_05745) 1144775..1145245 + 471 WP_002892026.1 YlaC family protein -
J7339_RS05790 (J7339_05750) 1145220..1146671 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
J7339_RS05795 (J7339_05755) 1146772..1147470 + 699 WP_002892021.1 GNAT family protein -
J7339_RS05800 (J7339_05760) 1147467..1147607 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
J7339_RS05805 (J7339_05765) 1147607..1147870 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T198018 WP_002892050.1 NZ_CP072555:1143699-1143917 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T198018 NZ_CP096839:3140235-3140498 [Mycobacterium tuberculosis variant bovis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT198018 WP_002892066.1 NZ_CP072555:1143298-1143672 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT198018 NZ_CP096839:3139950-3140231 [Mycobacterium tuberculosis variant bovis]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References