Detailed information of TA system TA198017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 4717..5266
• Replicon: plasmid pH7-11
• Accession: NZ_CP072554
• Organism: Acinetobacter lwoffii strain H7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: J7649_RS16690
• Protein ID: WP_219310320.1
• Coordinates: 4717..5007 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: J7649_RS16695
• Protein ID: WP_219310321.1
• Coordinates: 4991..5266 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7649_RS16670 (J7649_16670)	136..672	+	537	WP_005098306.1	plasmid replication DNA-binding protein	-
J7649_RS16675 (J7649_16675)	1165..1545	+	381	WP_219310317.1	fluoride efflux transporter CrcB	-
J7649_RS16680 (J7649_16680)	1580..2104	+	525	WP_219310318.1	inorganic diphosphatase	-
J7649_RS16685 (J7649_16685)	2191..3645	-	1455	WP_219310319.1	SulP family inorganic anion transporter	-
J7649_RS16860	3911..4108	-	198	WP_228738690.1	hypothetical protein	-
J7649_RS16690 (J7649_16690)	4717..5007	-	291	WP_219310320.1	type II toxin-antitoxin system YafQ family toxin	Toxin
J7649_RS16695 (J7649_16695)	4991..5266	-	276	WP_219310321.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
J7649_RS16700 (J7649_16700)	5777..6013	+	237	WP_219310309.1	hypothetical protein	-
J7649_RS16705 (J7649_16705)	6307..6588	+	282	WP_219310312.1	hypothetical protein	-
J7649_RS16710 (J7649_16710)	6634..6948	+	315	WP_219310314.1	helix-turn-helix transcriptional regulator	-
J7649_RS16715 (J7649_16715)	7012..7296	-	285	WP_219310315.1	hypothetical protein	-
J7649_RS16720 (J7649_16720)	7636..7827	-	192	WP_004728112.1	YqaE/Pmp3 family membrane protein	-
J7649_RS16725 (J7649_16725)	7857..8138	-	282	WP_147239659.1	mobilization protein	-
J7649_RS16730 (J7649_16730)	8348..9784	+	1437	WP_219310316.1	MobQ family relaxase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..11166	11166

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-95)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-85)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11214.19 Da
• Isoelectric Point: 8.0982

>T198017 WP_219310320.1 NZ_CP072554:c5007-4717 [Acinetobacter lwoffii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDDHLIKTGTVPDEYLPHPLIGEWRPHMECHVLPDLLLIWDVDKEN
NELILARIGSHSELFG

Nucleotide

• Length: 291 bp

>T198017 NZ_CP096839:c3099426-3099034 [Mycobacterium tuberculosis variant bovis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10249.60 Da
• Isoelectric Point: 4.6702

>AT198017 WP_219310321.1 NZ_CP072554:c5266-4991 [Acinetobacter lwoffii]
MTTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSAAEPKKFSSAQE
LFTDLEDDTDD

Nucleotide

• Length: 276 bp

>AT198017 NZ_CP096839:c3099638-3099423 [Mycobacterium tuberculosis variant bovis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA