Detailed information of TA system TA198011

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1755583..1756219
• Replicon: chromosome
• Accession: NZ_CP072549
• Organism: Acinetobacter lwoffii strain H7

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: J7649_RS08280
• Protein ID: WP_148334990.1
• Coordinates: 1755583..1755969 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9NUN9
• Locus tag: J7649_RS08285
• Protein ID: WP_004281484.1
• Coordinates: 1755962..1756219 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J7649_RS08265 (J7649_08265)	1750888..1753170	-	2283	WP_219307365.1	TRAP transporter large permease subunit	-
J7649_RS08270 (J7649_08270)	1753368..1753940	-	573	WP_219307367.1	rhombosortase	-
J7649_RS08275 (J7649_08275)	1754008..1755048	-	1041	WP_004281480.1	hypothetical protein	-
J7649_RS08280 (J7649_08280)	1755583..1755969	-	387	WP_148334990.1	hypothetical protein	Toxin
J7649_RS08285 (J7649_08285)	1755962..1756219	-	258	WP_004281484.1	succinate dehydrogenase assembly factor 2	Antitoxin
J7649_RS08290 (J7649_08290)	1756403..1757575	+	1173	WP_219307369.1	acyl-CoA dehydrogenase family protein	-
J7649_RS08295 (J7649_08295)	1757636..1759126	-	1491	WP_219307371.1	NAD(P)/FAD-dependent oxidoreductase	-
J7649_RS08300 (J7649_08300)	1759344..1759709	-	366	WP_004281488.1	50S ribosomal protein L17	-
J7649_RS08305 (J7649_08305)	1759728..1760735	-	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15239.38 Da
• Isoelectric Point: 9.9707

>T198011 WP_148334990.1 NZ_CP072549:c1755969-1755583 [Acinetobacter lwoffii]
MDNRCFKLKRSLCALAFQLFIFALLMYLLYQLLPIALWAVCAVIGLVIYQLFYRKTPQIEQFEYLDGREWSLTAKARPTR
RVCISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKLLTKLI

Nucleotide

• Length: 387 bp

>T198011 NZ_CP096839:c2843241-2842846 [Mycobacterium tuberculosis variant bovis]
ATGATCTTCGTCGACACGTCCTTCTGGGCTGCACTTGGCAACGCCGGCGACGCTCGGCACGGCACCGCGAAGAGGTTGTG
GGCCAGCAAACCGCCCGTGGTGATGACCTCCAACCATGTCCTGGGCGAGACCTGGACGCTGCTCAACCGGCGCTGCGGTC
ACCGCGCGGCGGTTGCCGCCGCTGCAATCCGCTTGAGCACCGTCGTTCGCGTCGAGCACGTAACAGCCGACCTGGAAGAG
CAGGCATGGGAATGGCTTGTACGCCACGACGAGCGAGAGTACTCGTTCGTCGATGCCACGAGCTTCGCGGTGATGCGAAA
GAAAGGCATCCAAAATGCGTATGCCTTCGATGGTGACTTCAGCGCGGCCGGATTTGTCGAGGTAAGACCCGAGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10340.82 Da
• Isoelectric Point: 4.6051

>AT198011 WP_004281484.1 NZ_CP072549:c1756219-1755962 [Acinetobacter lwoffii]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNHYLNAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT198011 NZ_CP096839:c2843483-2843238 [Mycobacterium tuberculosis variant bovis]
ATGCTAGTGGCGTATATTTGCCATGTGAAAAGGCTGCAGATCTACATCGACGAAGACGTTGACCGAGCGCTTGCTGTTGA
AGCGCGACGGCGGCGGACGTCGAAGGCGGCGCTGATCCGGGAGTACGTCGCTGAGCACCTCCGGCAGCCGGGCCCAGATC
CGGTCGATGCCTTCGTCGGATCGTTCGTGGGGGAAGCCGACTTGTCCGCGTCCGTCGACGACGTGGTTTACGGAAAGCAC
GAATGA

Structures

Antitoxin

• AlphaFold DB: N9NUN9