198009

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1274093..1274719 Replicon chromosome
Accession NZ_CP072548
Organism Aggregatibacter sp. 2125159857

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J5X96_RS06395 Protein ID WP_111277555.1
Coordinates 1274537..1274719 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J5X96_RS06390 Protein ID WP_111277557.1
Coordinates 1274093..1274506 (-) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5X96_RS06375 (J5X96_06375) 1270968..1271465 + 498 WP_209362403.1 5-(carboxyamino)imidazole ribonucleotide mutase -
J5X96_RS06380 (J5X96_06380) 1271606..1272694 + 1089 WP_209362405.1 5-(carboxyamino)imidazole ribonucleotide synthase -
J5X96_RS06385 (J5X96_06385) 1272784..1273974 + 1191 WP_209362407.1 amino acid aminotransferase -
J5X96_RS06390 (J5X96_06390) 1274093..1274506 - 414 WP_111277557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J5X96_RS06395 (J5X96_06395) 1274537..1274719 - 183 WP_111277555.1 type II toxin-antitoxin system HicA family toxin Toxin
J5X96_RS06400 (J5X96_06400) 1274901..1275248 + 348 WP_209362409.1 helix-turn-helix transcriptional regulator -
J5X96_RS06405 (J5X96_06405) 1275260..1275754 + 495 WP_209362411.1 hypothetical protein -
J5X96_RS09765 1276329..1276484 - 156 WP_245193452.1 hypothetical protein -
J5X96_RS06415 (J5X96_06415) 1276627..1277614 + 988 Protein_1226 iron ABC transporter permease -
J5X96_RS06420 (J5X96_06420) 1277624..1278274 + 651 Protein_1227 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6883.09 Da        Isoelectric Point: 10.8207

>T198009 WP_111277555.1 NZ_CP072548:c1274719-1274537 [Aggregatibacter sp. 2125159857]
VDSRKIIKMIEADGWIFHHATGSHYHFTHPIKKGIVTVPHPKKDLKKGTENSILKQARLK

Download         Length: 183 bp

>T198009 NZ_CP096839:2841273-2841686 [Mycobacterium tuberculosis variant bovis]
ATGGTGTTCTGCGTCGACACCAGCGCGTGGCATCACGCGGCGCGGCCGGAAGTTGCGCGCCGATGGTTGGCGGCCTTGTC
CGCGGACCAGATCGGCATCTGCGACCACGTGCGGTTGGAGATCCTGTACTCGGCGAACTCCGCTACCGACTACGACGCGC
TCGCCGACGAACTCGACGGCTTGGCCCGTATACCAGTCGGTGCCGAAACCTTTACGCGCGCATGCCAAGTCCAGCGTGAG
CTTGCCCACGTCGCCGGTCTGCATCACCGCAGCGTGAAGATCGCCGATCTTGTCATCGCCGCGGCGGCCGAACTTTCAGG
CACCATCGTGTGGCATTACGACGAGAACTATGACCGGGTCGCCGCCATCACCGGCCAACCTACGGAGTGGATCGTGCCGC
GCGGGACCCTTTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15142.25 Da        Isoelectric Point: 4.5312

>AT198009 WP_111277557.1 NZ_CP072548:c1274506-1274093 [Aggregatibacter sp. 2125159857]
MLYPIAIEPGDETHAFGVIVPDIPGCFSAGDTLEEAYANAKEAIAGHLELLVEMGEEVPLPTSMENHRNNPDFTNYGMFF
GVVDVDITHLLGKSEKINITMPAYLIKRIDDFVSTHREYKNRSSFLAKIAADKILSA

Download         Length: 414 bp

>AT198009 NZ_CP096839:2841725-2841982 [Mycobacterium tuberculosis variant bovis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References