198008

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 59672..60307 Replicon chromosome
Accession NZ_CP072548
Organism Aggregatibacter sp. 2125159857

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag J5X96_RS00275 Protein ID WP_209363529.1
Coordinates 59672..59848 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J5X96_RS00280 Protein ID WP_209363531.1
Coordinates 59891..60307 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J5X96_RS00275 (J5X96_00275) 59672..59848 + 177 WP_209363529.1 type II toxin-antitoxin system HicA family toxin Toxin
J5X96_RS00280 (J5X96_00280) 59891..60307 + 417 WP_209363531.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
J5X96_RS00285 (J5X96_00285) 60495..60665 + 171 WP_209363533.1 hypothetical protein -
J5X96_RS00290 (J5X96_00290) 60662..60940 + 279 WP_209363535.1 type II toxin-antitoxin system RelE/ParE family toxin -
J5X96_RS00295 (J5X96_00295) 61285..61596 + 312 WP_209363537.1 transcriptional regulator -
J5X96_RS00300 (J5X96_00300) 61593..61904 + 312 WP_209363539.1 helix-turn-helix domain-containing protein -
J5X96_RS00305 (J5X96_00305) 62075..62260 + 186 WP_245193465.1 hypothetical protein -
J5X96_RS00310 (J5X96_00310) 62253..62549 + 297 WP_209363541.1 type II toxin-antitoxin system RelE/ParE family toxin -
J5X96_RS00315 (J5X96_00315) 63136..63429 - 294 WP_209363543.1 type II toxin-antitoxin system RelE/ParE family toxin -
J5X96_RS00320 (J5X96_00320) 63419..63586 - 168 WP_209363545.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6703.86 Da        Isoelectric Point: 10.9086

>T198008 WP_209363529.1 NZ_CP072548:59672-59848 [Aggregatibacter sp. 2125159857]
MKQREFLRWLKAQGVETKEGTNHIKLYLNGKQSVLPRHPTKEIAKGTEFAIKKQLGLN

Download         Length: 177 bp

>T198008 NZ_CP096839:c2827805-2827386 [Mycobacterium tuberculosis variant bovis]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15468.87 Da        Isoelectric Point: 4.6843

>AT198008 WP_209363531.1 NZ_CP072548:59891-60307 [Aggregatibacter sp. 2125159857]
MLYPAKFEKEESGLYAVSFRDIPEAITCGDDYDDAVKMAKDALLTCMDFYFEDHRRVPLPSAPAEGEVLIELPASVFAKV
LLLNEMIEQNVSNAELARRINAKPQEVQRITNLGHITKIDTIAKAITALGKQFELRIV

Download         Length: 417 bp

>AT198008 NZ_CP096839:c2828026-2827802 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References