Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 3991650..3992437 | Replicon | chromosome |
| Accession | NZ_CP072539 | ||
| Organism | Escherichia coli O128ac:H12 strain AW1.7 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A2H9G3C1 |
| Locus tag | J7886_RS19340 | Protein ID | WP_001568519.1 |
| Coordinates | 3992060..3992437 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A2H9G3E7 |
| Locus tag | J7886_RS19335 | Protein ID | WP_000066236.1 |
| Coordinates | 3991650..3992009 (+) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J7886_RS19295 (3987346) | 3987346..3987492 | + | 147 | WP_023563913.1 | hypothetical protein | - |
| J7886_RS19300 (3987505) | 3987505..3987720 | + | 216 | WP_041036768.1 | hypothetical protein | - |
| J7886_RS19305 (3987834) | 3987834..3988244 | + | 411 | WP_042851426.1 | hypothetical protein | - |
| J7886_RS19310 (3988418) | 3988418..3989248 | + | 831 | WP_225858599.1 | hypothetical protein | - |
| J7886_RS19315 (3989337) | 3989337..3990155 | + | 819 | WP_016236913.1 | DUF932 domain-containing protein | - |
| J7886_RS19320 (3990423) | 3990423..3990893 | + | 471 | WP_000131762.1 | antirestriction protein | - |
| J7886_RS19325 (3990905) | 3990905..3991384 | + | 480 | WP_000437750.1 | DNA repair protein RadC | - |
| J7886_RS19330 (3991405) | 3991405..3991626 | + | 222 | WP_000691981.1 | DUF987 domain-containing protein | - |
| J7886_RS19335 (3991650) | 3991650..3992009 | + | 360 | WP_000066236.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| J7886_RS19340 (3992060) | 3992060..3992437 | + | 378 | WP_001568519.1 | TA system toxin CbtA family protein | Toxin |
| J7886_RS19345 (3992434) | 3992434..3992925 | + | 492 | WP_000777682.1 | DUF5983 family protein | - |
| J7886_RS19350 (3992957) | 3992957..3993160 | + | 204 | WP_000413747.1 | DUF957 domain-containing protein | - |
| J7886_RS19355 (3993241) | 3993241..3994086 | + | 846 | WP_016236912.1 | DUF4942 domain-containing protein | - |
| J7886_RS19365 (3994428) | 3994428..3995159 | - | 732 | WP_001300756.1 | DNA polymerase III subunit epsilon | - |
| J7886_RS19370 (3995224) | 3995224..3995691 | + | 468 | WP_000917883.1 | ribonuclease HI | - |
| J7886_RS19375 (3995688) | 3995688..3996410 | - | 723 | WP_001295200.1 | class I SAM-dependent methyltransferase | - |
| J7886_RS19380 (3996444) | 3996444..3997199 | + | 756 | WP_001052721.1 | hydroxyacylglutathione hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3987505..3997199 | 9694 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14211.00 Da Isoelectric Point: 7.4209
>T198000 WP_001568519.1 NZ_CP072539:3992060-3992437 [Escherichia coli O128ac:H12]
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKTTGLMTRNDYRTVTDITTGKYRGGHR
MQTQPLSSTQEATSRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRIDRHGF
STETQLPRLTSIDILRARKTTGLMTRNDYRTVTDITTGKYRGGHR
Download Length: 378 bp
>T198000 NZ_CP096839:c2208667-2208248 [Mycobacterium tuberculosis variant bovis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13127.02 Da Isoelectric Point: 7.0261
>AT198000 WP_000066236.1 NZ_CP072539:3991650-3992009 [Escherichia coli O128ac:H12]
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
MSNKIPTVNHDITEPWWGLKRSITPCFGARLVQSGNCLHYLADRASITGQFSDGDLRHLDQAFPLLLKQLELMLTSGELT
PRHQHCVTLYAKGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 360 bp
>AT198000 NZ_CP096839:c2208936-2208676 [Mycobacterium tuberculosis variant bovis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2H9G3C1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2H9G3E7 |