Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2687118..2687756 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J7886_RS13060 Protein ID WP_000813794.1
Coordinates 2687580..2687756 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J7886_RS13055 Protein ID WP_001270286.1
Coordinates 2687118..2687534 (-) Length 139 a.a.

Genomic Context

J7886_RS13065J7886_RS13080J7886_RS13035J7886_RS13040J7886_RS13045J7886_RS13050J7886_RS13055J7886_RS13060J7886_RS13070J7886_RS13075
Location: 2687978..2688208 (231 bp)
Type: Others
Protein ID: WP_072188679.1
Location: 2690923..2692137 (1215 bp)
Type: Others
Protein ID: WP_001324881.1
Location: 2682270..2683211 (942 bp)
Type: Others
Protein ID: WP_001251313.1
Location: 2683212..2684225 (1014 bp)
Type: Others
Protein ID: WP_000220434.1
Location: 2684243..2685388 (1146 bp)
Type: Others
Protein ID: WP_000047430.1
Location: 2685633..2687039 (1407 bp)
Type: Others
Protein ID: WP_000760630.1
Location: 2687118..2687534 (417 bp)
Type: Antitoxin
Protein ID: WP_001270286.1
Location: 2687580..2687756 (177 bp)
Type: Toxin
Protein ID: WP_000813794.1
Location: 2688300..2690261 (1962 bp)
Type: Others
Protein ID: WP_001488038.1
Location: 2690334..2690870 (537 bp)
Type: Others
Protein ID: WP_000429169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
J7886_RS13035 (2682270)2682270..2683211-942WP_001251313.1ABC transporter permease-
J7886_RS13040 (2683212)2683212..2684225-1014WP_000220434.1ABC transporter ATP-binding protein-
J7886_RS13045 (2684243)2684243..2685388-1146WP_000047430.1ABC transporter substrate-binding protein-
J7886_RS13050 (2685633)2685633..2687039-1407WP_000760630.1PLP-dependent aminotransferase family protein-
J7886_RS13055 (2687118)2687118..2687534-417WP_001270286.1type II toxin-antitoxin system antitoxin HicBAntitoxin
J7886_RS13060 (2687580)2687580..2687756-177WP_000813794.1type II toxin-antitoxin system mRNA interferase toxin HicAToxin
J7886_RS13065 (2687978)2687978..2688208+231WP_072188679.1YncJ family protein-
J7886_RS13070 (2688300)2688300..2690261-1962WP_001488038.123S rRNA 5-hydroxycytidine C2501 synthase-
J7886_RS13075 (2690334)2690334..2690870-537WP_000429169.1DNA-binding transcriptional regulator SutR-
J7886_RS13080 (2690923)2690923..2692137+1215WP_001324881.1BenE family transporter YdcO-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T197997 WP_000813794.1 NZ_CP072539:c2687756-2687580 [Escherichia coli O128ac:H12]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T197997 NZ_CP096839:c2190526-2190197 [Mycobacterium tuberculosis variant bovis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT197997 WP_001270286.1 NZ_CP072539:c2687534-2687118 [Escherichia coli O128ac:H12]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT197997 NZ_CP096839:c2190900-2190523 [Mycobacterium tuberculosis variant bovis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6HPB

Antitoxin

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Source
ID
Structure
No matching records found

References