Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2687118..2687756 Replicon chromosome
Accession NZ_CP072539
Organism Escherichia coli O128ac:H12 strain AW1.7

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag J7886_RS13060 Protein ID WP_000813794.1
Coordinates 2687580..2687756 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag J7886_RS13055 Protein ID WP_001270286.1
Coordinates 2687118..2687534 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J7886_RS13035 (2682270) 2682270..2683211 - 942 WP_001251313.1 ABC transporter permease -
J7886_RS13040 (2683212) 2683212..2684225 - 1014 WP_000220434.1 ABC transporter ATP-binding protein -
J7886_RS13045 (2684243) 2684243..2685388 - 1146 WP_000047430.1 ABC transporter substrate-binding protein -
J7886_RS13050 (2685633) 2685633..2687039 - 1407 WP_000760630.1 PLP-dependent aminotransferase family protein -
J7886_RS13055 (2687118) 2687118..2687534 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
J7886_RS13060 (2687580) 2687580..2687756 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
J7886_RS13065 (2687978) 2687978..2688208 + 231 WP_072188679.1 YncJ family protein -
J7886_RS13070 (2688300) 2688300..2690261 - 1962 WP_001488038.1 23S rRNA 5-hydroxycytidine C2501 synthase -
J7886_RS13075 (2690334) 2690334..2690870 - 537 WP_000429169.1 DNA-binding transcriptional regulator SutR -
J7886_RS13080 (2690923) 2690923..2692137 + 1215 WP_001324881.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T197997 WP_000813794.1 NZ_CP072539:c2687756-2687580 [Escherichia coli O128ac:H12]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T197997 NZ_CP096839:c2190526-2190197 [Mycobacterium tuberculosis variant bovis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT197997 WP_001270286.1 NZ_CP072539:c2687534-2687118 [Escherichia coli O128ac:H12]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT197997 NZ_CP096839:c2190900-2190523 [Mycobacterium tuberculosis variant bovis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References